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Pseudechis guttatus venom proteome: Insights into evolution and toxin clustering.
Although previous studies contributed to the knowledge of the major components of this venom, this study revealed some yet undescribed protein species, as well as new toxins, such as CRiSPs, phospholipase B, transferrin-like protein and ecto 5'-nucleotidase. Expand
Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants.
The venome of Pseudonaja textilis is analysed by combining high throughput proteomics and transcriptomics to further characterize the components of this venom, and indicates that splicing variants can be an important source of toxin variation. Expand
Proteomic analysis of the rare Uracoan rattlesnake Crotalus vegrandis venom: Evidence of a broad arsenal of toxins.
The results point to a broad arsenal of toxins in C. vegrandis venom: PIII and PII metalloproteases, crotoxin subunits, other phospholipases, isoforms of serine proteases and lectins, l-amino-acid oxidase, nerve growth factor, as well as other less abundant toxins. Expand
Replacement and parallel simplification of non-homologous proteinases maintain venom phenotypes in rear-fanged snakes.
A new highly expressed MMP subtype, named snake venom MMP (svMMP), is revealed, which originated independently on at least three occasions from an endogenous MMP-9, and provides rare evidence on how relevant phenotypic traits can be optimized via natural selection on non-homologous genes, yielding alternate biochemical components. Expand
Isolation and biochemical characterization of bradykinin-potentiating peptides from Bitis gabonica rhinoceros
The aim of this work was to isolate and characterize novel BPPs from the venom of Bitis gabonica rhinoceros, and based on the sequenced peptides, two non-canonical sequences were detected. Expand
Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 lineage (20H/501Y.V2) in Brazil
The analysis allowed the detection, for the first time in Brazil, of the South African variant of concern (VOC), the B.1.1 lineage, and highlights the importance to increase active monitoring to ensure the rapid detection of new SARS-CoV-2 variants with a potential impact in pandemic control and vaccination strategies. Expand
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
The results indicate that venom complexity evolves in response to phylogenetic diversity in a community of species, likely reflecting divergence in the physiological targets of venom. Expand
Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome
The jararaca lancehead genome provides a comprehensive road map of the genomic context of pitviper toxin genes, and the results support the idea of a locally assembled venom arsenal in which the most clinically relevant toxin families expanded through posterior gene duplications, regardless of whether they originated by duplication or gene co-option. Expand
Genomic monitoring unveil the early detection of the SARS‐CoV‐2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil
Through analysis of 210 SARS-CoV-2 complete genomes obtained from the largest regional health departments, the P.1 lineage predominance was demonstrated and allowed the early detection of the South African strain for the first time in Brazil. Expand
Long reads DNA sequencing in genomics and venom gland transcriptomics.
  • V. Viala
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 20 April 2020