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Active defense under oxidative stress. The antioxidant responsive element
This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is important for cell defense under conditions
Fatty Acids in Energy Metabolism of the Central Nervous System
This review made an attempt to reconcile β-oxidation of fatty acids by astrocytic mitochondria with the existing hypothesis on regulation of aerobic glycolysis and suggests that, under condition of neuronal excitation, both metabolic pathways may exist simultaneously.
Interaction of GSTM1, GSTT1, and GSTP1 Genotypes in Determination of Predisposition to Atopic Dermatitis
The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far
Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis
The prevalence of GSTP 1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control) is determined and both homozygotes are at high risk of developing atopy dermatitis.
Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats.
It is concluded that mitochondrial dysfunction appears to mediate or possibly even initiate pathological molecular cascades of AD-like pathology in OXYS rats and can be considered a predictor of the early development of the late-onset form of AD in humans.
[Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma].
It is concluded that null-genotypes are associated with susceptibility to BA in children and combination of plus genotypes protected PS patients from all unfavorable peculiarities of disease.
Analysis of associations of NAT2 gene polymorphisms with the risk of lung cancer
The incidence of 5 polymorphisms of N-acetyltransferase-2 gene was evaluated in patients with lung cancer and it was found that opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible.
Novel Conjugate of Moxifloxacin and Carboxymethylated Glucan with Enhanced Activity against Mycobacterium tuberculosis
ABSTRACT Mycobacterium tuberculosis is an intracellular pathogen that persists within macrophages of the human host. One approach to improving the treatment of tuberculosis (TB) is the targeted
Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia
Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 µg/kg simvastatin exhibited
Functional Analysis of the Unique Cytochrome P450 of the Liver Fluke Opisthorchis felineus
The research on the human liver fluke Opisthorchis felineus suggests that the CYP function is linked to worm metabolism and detoxification, and is a potential drug target.