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Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?
TLDR
This exercise prioritized the most critical questions regarding the effects of PPCPs on human and ecological health in order to ensure that future resources will be focused on the most important areas.
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
TLDR
Whether commercially available botanicals directly affect the primary brain enzymes responsible for gamma-aminobutyric acid (GABA) metabolism is determined and possible in vivo mode of action is discussed.
Neuroendocrine regulation of gonadotrophin II release and gonadal growth in the goldfish, Carassius auratus.
TLDR
The goldfish, a member of the carp family, is a widely used model for reproductive neuroendocrine studies of economically important fish and the principal stimulatory and inhibitory systems regulating GTH-II release are the gonadotrophin-releasing hormone (GnRH) and dopamine neurones in the preoptic-hypothalamic region.
Pharmaceuticals as Neuroendocrine Disruptors: Lessons Learned from Fish on Prozac
TLDR
The evolutionary conservation of the 5-HT transporter is described and the disruptive effects of fluoxetine on several physiological endpoints, including involvement of neuroendocrine mechanisms are reviewed, which may be helpful in designing targeted approaches for future risk assessments of pharmaceuticals disrupting the neuro endocrine system in general.
Low Levels of the Herbicide Atrazine Alter Sex Ratios and Reduce Metamorphic Success in Rana pipiens Tadpoles Raised in Outdoor Mesocosms
TLDR
Exposure to low concentrations of ATZ in experimental mesocosms alters gonadal differentiation and metamorphosis in developing R. pipiens, indicating that ATZ treatments significantly reduced metamorphic success without affecting body weight, snout–vent length, or age at meetamorphosis.
Spawning energetics of Arctic cod (Boreogadus saida) in relation to seasonal development of the ovary and plasma sex steroid levels
TLDR
Under laboratory conditions (at 1.0 °C), female Arctic cod became ripe and started to spawn in mid-February, which concurred with field observations, and Arctic cod are repeat spawners, at least under laboratory conditions, in spite of the large amount of energy allocated to reproduction.
Mercury‐induced reproductive impairment in fish
TLDR
Data from both laboratory and field studies supporting the hypothesis that mercury in the aquatic environment impacts the reproductive health of fish are summarized, suggesting that the inhibitory effects of mercury on reproduction occur at multiple sites within the reproductive axis.
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