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Inactivating mutations of acetyltransferase genes in B-cell lymphoma
TLDR
The results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin’s lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms.
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Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma
TLDR
By combining next-generation sequencing and copy number analysis, it is shown that the DLBCL coding genome contains, on average, more than 30 clonally represented gene alterations per case and novel dysregulated pathways underlying its pathogenesis are identified.
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Genetics of follicular lymphoma transformation.
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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.
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Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
TLDR
Evidence that HSMI is associated with infection with piscine reovirus (PRV) is provided, and measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon populations.
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BRAF mutations in hairy-cell leukemia.
TLDR
The BRAF V600E mutation was present in all patients with HCL who were evaluated, and may have implications for the pathogenesis, diagnosis, and targeted therapy of HCL.
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The integrated landscape of driver genomic alterations in glioblastoma
TLDR
A computational platform that integrates the analysis of copy number variations and somatic mutations and unravels the landscape of in-frame gene fusions in glioblastoma provides insights into the pathogenesis of gliOBlastoma and highlights new targets for therapeutic intervention.
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The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development
TLDR
Notch2 mutations represent the most frequent lesion in splenic marginal zone lymphoma and are associated with atypical granuloma-like lesions.
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Mammalian karyotype evolution
TLDR
This work discusses how chromosome rearrangements come about, and shows how their analysis can determine the evolutionary relationships of all mammals and their descent from a common ancestor.
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Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus.
TLDR
The evolution of the H1N1 virus is described by Vladimir Trifonov, Hossein Khiabanian, and Raul Rabadan.
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