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Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the innate immune system. We identify the hostExpand
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Focused Specificity of Intestinal Th17 Cells towards Commensal Bacterial Antigens
T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune disease pathogenesis. They are most abundant in the small intestine lamina propria, where their presence requiresExpand
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Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization.
The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus aureus has been previously shown to be reliant on the acquisition of iron from host hemoproteins. TheExpand
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Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion.
Recent evidence indicates that the secreted Helicobacter pylori vacuolating toxin (VacA) inhibits the activation of T cells. VacA blocks IL-2 secretion in transformed T cell lines by suppressing theExpand
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The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
SUMMARY The ability to produce water-soluble proteins with the capacity to oligomerize and form pores within cellular lipid bilayers is a trait conserved among nearly all forms of life, includingExpand
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Staphylococcus aureus Redirects Central Metabolism to Increase Iron Availability
Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host. However, the regulatory impact of host iron sources on S. aureus gene expression remains unknown. InExpand
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Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis
Staphylococcus aureus is an important pathogen that continues to be a significant global health threat because of the prevalence of methicillin‐resistant S. aureus strains (MRSA). The pathogenesis ofExpand
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CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore-forming bi-componentExpand
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Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection.
The Staphylococcus aureus leukotoxin ED (LukED) is a pore-forming toxin required for the lethality associated with bacteremia in murine models. LukED targets the chemokine receptor CCR5 to kill TExpand
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Protein-protein interactions among Helicobacter pylori cag proteins.
Many Helicobacter pylori isolates contain a 40-kb region of chromosomal DNA known as the cag pathogenicity island (PAI). The risk for development of gastric cancer or peptic ulcer disease is higherExpand
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