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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
- Sreenivasa Ramaiahgari, M. W. D. Braver, +4 authors L. Price
- Biology, Medicine
- Archives of Toxicology
- 6 March 2014
Immortalized hepatocyte cell lines show only a weak resemblance to primary hepatocytes in terms of gene expression and function, limiting their value in predicting drug-induced liver injury (DILI).… Expand
Focal Nodular Hyperplasia and Hepatic Adenoma: Epidemiology and Pathology
Focal nodular hyperplasia (FNH) and hepatic adenoma (HA) represent the most frequent non-vascular benign liver tumors. They are often asymptomatic. The widespread use of high-resolution imaging… Expand
Hepatic and extrahepatic scavenger receptors: function in relation to disease.
- V. Terpstra, E. V. Van Amersfoort, A. V. van Velzen, J. Kuiper, T. V. van Berkel
- Medicine, Biology
- Arteriosclerosis, thrombosis, and vascular…
- 1 August 2000
Scavenger receptors (SRs) have been of major interest in the study of atherogenesis over the past decade. They were first described for macrophages as alternative receptors to the LDL receptor in the… Expand
Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium.
- M. Bieze, Jacomina W. van den Esschert, +5 authors Saffire S.K.S. Phoa
- AJR. American journal of roentgenology
- 23 November 2012
OBJECTIVE The purpose of this article is to prospectively determine the sensitivity of hepatobiliary phase gadoxetate disodium-enhanced MRI combined with standard MRI in differentiating focal nodular… Expand
Comparison of interobserver agreement of magnetic resonance elastography with histopathological staging of liver fibrosis
PurposeMR elastography (MRE) can serve as an accurate surrogate marker of liver fibrosis. For any diagnostic test that is to replace the current reference standard, interobserver agreement should be… Expand
Cell surface expression of mouse macrosialin and human CD 68 and their role as macrophage receptors for oxidized low density lipoprotein
We have previously identified a 94to 97-kDa oxidized low density lipoprotein (LDL)-binding protein inmouse macrophages asmacrosialin (MS), amember of the lamp family. Earlier immunostaining studies… Expand
Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice.
In vitro studies have shown that damaged red cells and apoptotic cells are efficiently phagocytosed by scavenger receptors from macrophages, even under non-opsonizing conditions. Damaged red blood… Expand
Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with pegylated interferon-α2a and adefovir.
BACKGROUND In this study, we aimed to identify baseline predictors of response in chronic hepatitis B patients treated with a combination of pegylated interferon (PEG-IFN)-α2a and adefovir. METHODS… Expand
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha‐2a and adefovir
- B. Takkenberg, V. Terpstra, +5 authors H. Reesink
- Journal of gastroenterology and hepatology
- 1 October 2011
Background and Aim: We investigated whether intrahepatic markers could predict response in chronic hepatitis B virus (HBV) patients treated with peg‐interferon and adefovir for 48 weeks.
ABCB4 deficiency: A family saga of early onset cholelithiasis, sclerosing cholangitis and cirrhosis and a novel mutation in the ABCB4 gene
- G. Denk, H. Bikker, +5 authors T. Pusl
- Medicine, Biology
- Hepatology research : the official journal of the…
- 30 August 2010
Gallstones are very common. However, there is a small group of patients with low phospholipid‐associated cholelithiasis (LPAC) that is characterized by symptomatic cholelithiasis at a young age (<40… Expand