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Repurposing the CRISPR-Cas9 system for targeted DNA methylation
TLDR
A CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co–expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide is developed.
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Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract.
TLDR
Hawthorn extract produced dose-dependent gastroprotective activity, with the efficacy comparable to that of the reference drug, and its moderate bactericidal activity, especially against gram-positive bacteria Micrococcus flavus, Bacillus subtilis, and Lysteria monocytogenes, with no effect on Candida albicans.
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Antioxidant properties of the anthocyanin-containing ultrasonic extract from blackberry cultivar “Čačanska Bestrna”
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Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man’s Beard (Usnea barbata)
TLDR
Investigation of chemical profile and stated biological activities of the supercritical CO2 extract of old man’s beard compared to the extracts obtained using the conventional techniques found a good correlation of usnic acid content in the extracts and their antioxidant capacity was established, extricating SCE as the most active one.
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Antioxidant activity and phenolic compounds in 10 selected herbs from Vrujci Spa, Serbia
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Phytochemical analysis and gastroprotective activity of an olive leaf extract
Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat dia- betes mellitus and heart disease. Whether olive…
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Anti-inflammatory, gastroprotective, and cytotoxic effects of Sideritis scardica extracts.
TLDR
It seems that phenolic compounds (apigenin, luteolin, and their corresponding glycosides) are responsible for the diethyl ether extract cytotoxic effect, and induction of oxidative stress might be involved in its cytotoxicity.
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Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts.
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Chemical and Antimicrobial Evaluation of Supercritical and Conventional Sideritis scardica Griseb., Lamiaceae Extracts
TLDR
A comparison between conventional and alternative extraction methods regarding the qualitative and quantitative composition of the obtained extracts as analyzed by GC and GC-MS techniques and their anitimicrobial activity is reported.
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Antagonistic and synergistic epigenetic modulation using orthologous CRISPR/dCas9-based modular system
TLDR
A modular and extensible CRISPR/dCas9-based toolbox for epigenetic editing and direct gene regulation is presented and strong and persistent synergistic effect on gene transcription is revealed, up to 30 days following cell transfection, suggesting involvement of epigenetic mechanisms in maintenance of the reactivated state.
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