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Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.
The inhibitory effects of rhuMAb-E25 on allergen-induced EAR suggest that it may be an effective, novel antiallergic treatment for asthma.
Asthma control versus asthma severity.
Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine.
A single dose of 1.25 mg nebulised R-salbutamol produced equivalent bronchoprotection, bronchodilation, restlessness, and tachycardia as did 2.5 mg of racemic sal butamol.
Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol.
Tolerance to the acute bronchoprotective effect of salmeterol was significant after the first two doses and persisted after the seventh dose, indicating that tolerance is not prevented by use of inhaled corticosteroids.
Functional antagonism: tolerance produced by inhaled beta 2 agonists.
The topic of tolerance to the bronchoprotective effect of inhaled 12 agonist and its potential clinical relevance is discussed.
Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+.
Data indicate trypsin-like proteases and elastase play an important role in the clearance of alveolar fluid by increasing ion transport and paracellular resistance via a PLC-initiated rise of intracellular Ca(2+).