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Structure of the insulin receptor ectodomain reveals a folded-over conformation
The structure reveals the domain arrangement in the disulphide-linked ectodomain dimer, showing that the insulin receptor adopts a folded-over conformation that places the ligand-binding regions in juxtaposition, very different from previous models. Expand
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.
The active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state, but in contrast to the NDV structures, no ligand-induced structural changes that extend beyond the active site and modify the dimer interface are observed. Expand
Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.
It is suggested that IgNARs originated as cell-surface adhesion molecules coopted to the immune repertoire and represent an evolutionary lineage independent of variable heavy chain/variable light chain type antibodies. Expand
Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity
A new class of specific, mechanism-based anti-influenza drugs that function through the formation of a stabilized covalent intermediate in the influenza neuraminidase enzyme are reported, with efficacies comparable to that of the neuraminIDase inhibitor zanamivir and with broad-spectrum activity against drug-resistant strains in vitro. Expand
Electron density and optical anisotropy in rhombohedral carbonates. III. Synchrotron X-ray studies of CaCO3, MgCO3 and MnCO3
Diffraction-deformation electron-density (Δp) images for small, naturally faced single crystals of synthetic calcite (CaCO 3 ), magnesite (MgCO 3 ) and mineral rhodochrosite (MnCO 3 ) were measuredExpand
Ammonium hydroxide treatment of Aβ produces an aggregate free solution suitable for biophysical and cell culture characterization
Using dynamic light scattering, size exclusion chromatography and small angle X-ray scattering, it is shown that HFIP pretreated Aβ peptide solutions displaying an increased proportion of oligomeric and aggregated material and an increased propensity to aggregate. Expand
X-ray study of the electron density in calcite, CaCO3
The electron density in synthetic calcite, CaCO 3 , has been determined using diffraction data for a naturally faced single crystal measured with X-ray Mo Kα (λ=0.71073 A) radiation. ExtinctionExpand
Synchrotron X-ray study of the electron density in α-Al2O3
Structure factors for synthetic haematite, α-Fe 2 O 3 , have been measured for two small crystals using focused λ=0.7 A synchrotron radiation. The structure factors from the two data sets areExpand
The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.
Within the past year, structures of partial and complete ectodomains of the IR have been published that show that the extracellular region of the receptor adopts an unexpected 'inverted V' conformation relative to the cell membrane, providing insight into the potential mechanism of activation of theIR. Expand