V. Stonik

Publications509
h-index41
Citations6,612
Highly Influential Citations163
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Triterpene glycosides from sea cucucmbers (holothurioidea, echinodermata). Biological activities and functions
Abstract The holothuroid triterpene glycosides have strong membranolytic action against cellular and model membranes containing Δ5-sterols as result of the formation of single-ion channels and more…
Holothurins B(2), B(3), and B(4), new triterpene glycosides from mediterranean sea cucumbers of the genus holothuria.
TLDR
Three new monosulfated biosides, holothurins B(2) (1), B(3) (2), and B(4) (3), along with the previously known holothsurins A (4) and B (5) were isolated from the sea cucumber H. polii.
Sea Cucumbers Triterpene Glycosides, the Recent Progress in Structural Elucidation and Chemotaxonomy
TLDR
All three families belonging to the order Aspidochirotida: Holothuriidae, Stichopodidae and Synallactidae have similar and parallel trends in evolution of the glycosides carbohydrate chains, namely from non-sulfated hexaosides to sulfated tetraosides.
Monanchocidin: a new apoptosis-inducing polycyclic guanidine alkaloid from the marine sponge Monanchora pulchra.
TLDR
Compound 1 shows pro-apoptotic and cytoxic activities and the structure of 1 was assigned on the basis of detailed analysis of 1D and 2D NMR spectra, mass spectrometry, and results of chemical transformations.
Secondary Metabolites from Echinoderms as Chemotaxonomic Markers
TLDR
The structures of some secondary metabolites and their distribution in the Phylum Echinoder-mata are described and triterpene glycosides from sea cucumbers, which have been utilized in a meaningful classification of Holothurioidea are described.
Differential effects of triterpene glycosides, frondoside A and cucumarioside A2‐2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells
TLDR
This work compared the effects of frondoside A and A2‐2 for cell death‐inducing capability with close attention paid to structure–activity relationships and suggested that holothurians may induce apoptosis of leukemic cells caspase‐dependently or ‐independently, depending on the Holothurian structure.
Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra.
TLDR
Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 540, 200, 110, 830, and 650 nM, respectively.
The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus).
TLDR
Results confirmed that actinoporin RTX-A from H. crispa, at least partially, might exhibit cancer-preventive and anticancer cytotoxic properties through the induction of p53-independent apoptosis and inhibition of the oncogenic AP-1 and NF-kappaB nuclear factors activity.
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
TLDR
The results suggest that FrA is a promising new drug for the treatment of mCRPC, with high efficacy in human prostate cancer cells, while non‐malignant cells were less sensitive to it.
Antitumor activity of the immunomodulatory lead Cumaside.
A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity…
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