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The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer
Beta-transducin repeats-containing proteins (β-TrCP) serve as the substrate recognition subunits for the SCFβ-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylatedExpand
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S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9
We previously showed that the calcium-binding protein S100A4 is overexpressed during the progression of prostate cancer (CaP) in humans and in the TRAMP (transgenic adenocarcinoma of the mouseExpand
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Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.
The Hedgehog (Hh) signaling pathway plays a crucial role in embryogenesis and has been linked to the development of several human malignancies. The transcription factor Gli2 plays a key role in theExpand
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CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.
miRNAs are largely known to base pair with the 3'UTR of target mRNAs, downregulating their stability and translation. mRNA of betaTrCP1 ubiquitin ligase is very unstable, but unlike the majority ofExpand
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Sonic hedgehog signaling in Basal cell nevus syndrome.
The hedgehog (Hh) signaling pathway is considered to be a major signal transduction pathway during embryonic development, but it usually shuts down after birth. Aberrant Sonic hedgehog (Shh)Expand
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IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
Insulin-like growth factor 2 mRNA-binding protein-1 (IMP-1) is an oncofetal protein that binds directly to and stabilizes oncogenic c-Myc and regulates, in turn, its posttranscriptional expressionExpand
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Gli2 Is Targeted for Ubiquitination and Degradation by β-TrCP Ubiquitin Ligase*
The Hedgehog (Hh) signaling pathway plays a crucial role in embryogenesis and has been linked to the development of several human malignancies. The transcription factor Gli2 plays a key role in theExpand
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High frequency of K‐ras mutations in normal appearing lung tissues and sputum of patients with lung cancer
  • Marina S. Yakubovskaya, V. Spiegelman, +9 authors Z. Ronai
  • Medicine
  • International journal of cancer
  • 11 December 1995
To evaluate the possible use of mutant ras as a biomarker for lung cancer, we have analyzed “normal appearing” lung tissue, lung tumor, lung metastases and sputum samples from patients with non‐smallExpand
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Negative Regulation of Prolactin Receptor Stability and Signaling Mediated by SCFβ-TrCP E3 Ubiquitin Ligase
ABSTRACT Ubiquitin-dependent degradation of hormone receptors is emerging as a key mechanism that regulates the magnitude and duration of hormonal effects on cells and tissues. The pituitary hormoneExpand
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