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Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis
While cholesterol metabolism by M. tuberculosis appears to be most important during the chronic stage of infection, it begins much earlier and may contribute to the pathogen's dissemination within the host, providing insights into the binding of catechols by extradiol dioxygenases and facilitate inhibitor design.
Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria
A pathway for the final steps of steroid catabolism is proposed in which the 5-member ring is hydrolyzed by EchA20, followed by hydrolysis of the 6- member ring by IpdAB, and it is predicted that cholesterolCatabolism yields four propionyl-CoAs, four acetyl- CoAs, one pyruvate, and one succinyl-CoA.
Impacts of structural photomodification on the toxicity of environmental contaminants: anthracene photooxidation products.
High performance liquid chromatography analysis of anthracene photooxidation revealed a complex array of oxidation products; prevalent among these were anthraquinone (ATQ) and hydroxy-anthraquinones (hATQs), which were found to be toxic, and when UV radiation was present in the light source toxicity was generally enhanced.
Palladium-catalyzed cross-coupling: a historical contextual perspective to the 2010 Nobel Prize.
This Review attempts to trace the historical origin of these powerful reactions, and outline the developments from the seminal discoveries leading to their eminent position as appreciated and applied today.