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Ligand-receptor-mediated drug delivery: an emerging paradigm in cellular drug targeting.
Receptor-mediated cellular events have received major attention in the field of drug/gene delivery in the past few years. These events, which are mediated through the endogenous ligands/epitopes,Expand
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Pilosebaceous unit: anatomical considerations and drug delivery opportunities
Pilosebaceous unit is composed of hair follicle, hair shaft and sebaceous gland. This three-dimensional complex structure present on the surface of mammalian skin has been considered as an importantExpand
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Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases
Advances in the understanding of the aetiology, epidemiology, pathogenesis and microbiology of periodontal pocket flora have revolutionized the strategies for the management of intraperiodontalExpand
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Ligand directed macrophage targeting of amphotericin B loaded liposomes.
Two types of ligand anchored multilamellar liposomes (MLVs) containing amphotericin B (Amp B) were prepared. The MLVs consisting of soya phosphatidylcholine (PC) and cholesterol (Chol) were coatedExpand
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High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a
A simple, precise, accurate and rugged reversed-phase high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of five permeabilityExpand
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Mannosylated liposomes for bio-film targeting.
Vesicular systems in general are investigated to achieve bacterial bio-film targeting as their architecture mimics bio-membranes in terms of structure and bio-behavior. This paper elaborates upon theExpand
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Potential of polysaccharide anchored liposomes in drug delivery, targeting and immunization.
  • V. Sihorkar, S. Vyas
  • Biology, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a…
  • 1 May 2001
PURPOSE Recently the emphasis has been laid upon the carbohydrate mediated liposomal interactions with the target cells. Among the various carbohydrate ligands, such as glycoproteins, glycolipids,Expand
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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: part 2.
Melanin concentrating hormone receptor 1 (MCHR1) antagonists have potential for the treatment of obesity and several CNS disorders. In the preceding article, we have described a novel series ofExpand
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Efficient throughput method for hygroscopicity classification of active and inactive pharmaceutical ingredients by water vapor sorption analysis
The conventional method of hygroscopicity determination proposed by Callahan and co-workers utilizes more sample and time, may not be precise in all the cases, and is a relatively broaderExpand
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Preparation, characterization and in vitro antimicrobial activity of metronidazole bearing lectinized liposomes for intra-periodontal pocket delivery.
Liposomes constructed of egg phosphatidylcholine (EPC), cholesterol (Chol) and stearoylamine (SA) were coated with lectin (Concanavalin-A). These lectinized liposomes were found to retain the ligandExpand
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