• Publications
  • Influence
Investigation of guanosine-quartet assemblies by vibrational and electronic circular dichroism spectroscopy, a novel approach for studying supramolecular entities.
TLDR
Temperature-dependent experiments indicate that the long-range supramolecular aggregates are dissociated by increasing temperature into less ordered species, monomers, or other intermediates in equilibrium, as indicated by MS experiments. Expand
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
TLDR
Based on the initial promising biochemical data and a safer in vivo toxicity compared to tacrine, S-K1035 was administered to scopolamine-treated rats being able to dose-dependently revert amnesia and to exert a moderate inhibition potency against neuronal nitric oxide synthase. Expand
Role of different β‐turns in β‐hairpin conformation and stability studied by optical spectroscopy
TLDR
Model β‐hairpin peptides based on variations in the turn sequence of Cochran's tryptophan zipper peptide, SWTWENGKWTWK, were studied using electronic circular dichroism, fluorescence, and infrared spectroscopies to provide insight to the complex folding pathways of these small, well‐folded peptides. Expand
Vibrational circular dichroism of tetraphenylporphyrin in peptide complexes? A computational study.
TLDR
In order to estimate whether induced optical activity in chiral complexes interferes with the signal of peptide vibrations, the vibrational circular dichroism (VCD) spectra of TPP were simulated and no significant contribution to VCD signal from the TPP residue was found in experimental spectra. Expand
Conformational study of melectin and antapin antimicrobial peptides in model membrane environments.
TLDR
A significant content of α-helical conformation is found in the solutions of negatively charged liposomes mimicking the bacterial membrane, thus correlating with the antimicrobial activity of the studied peptides. Expand
Determination of molecular structure in solution using vibrational circular dichroism spectroscopy: the supramolecular tetramer of S-2,2'-dimethyl-biphenyl-6,6'-dicarboxylic acid.
TLDR
The study is the first to use VCD spectroscopy to determine the structure of a supramolecular species, and predicts that the "aaab" conformation is the predominant conformation. Expand
Vibrational Circular Dichroism of 1,1‘-Binaphthyl Derivatives: Experimental and Theoretical Study
Absorption and vibrational circular dichroism (VCD) spectra of six 1,1‘-binaphthyl derivatives were measured and analyzed on the basis of ab initio modeling. The spectra of both enantiomers wereExpand
Induced axial chirality in the biphenyl core of the cα-tetrasubstituted α-amino acid residue Bip and subsequent propagation of chirality in (Bip)n/Val oligopeptides
In the dipeptides Boc-Bip-L-Val-OMe and Boc-Bip-D-Val-OMe, an induced axial chirality in the biphenyl core of the Bip residue, a conformationally labile, proatropoisomeric Cα,α-disubstituted glycine,Expand
The complete chirospectroscopic signature of the peptide 310‐helix in aqueous solution
TLDR
A Fourier transform infrared absorption and NMR analysis in deuterated chloroform and aqueous solutions of the heptapeptide and two side‐chain protected synthetic precursors confirmed the working hypothesis that all oligomers are folded in the 310‐helical conformation. Expand
IR study of cross-strand coupling in a β-hairpin peptide using isotopic labels
Model β-hairpin peptides can be used to develop understanding of fundamental elements of β-sheet secondary structure formation and stability. We have studied two 13C-labeled variants of a β-hairpinExpand
...
1
2
3
4
5
...