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Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
Chromosome conformation capture approaches have shown that interphase chromatin is partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological domains. ThisExpand
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A role for cohesin in T cell receptor rearrangement and thymocyte differentiation
Cohesin enables post-replicative DNA repair and chromosome segregation by holding sister chromatids together from the time of DNA replication in S phase until mitosis. There is growing evidence thatExpand
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Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance
Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulatingExpand
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Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin.
In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin complex associates with CTCF and with active gene regulatory elements to form long-range interactions between itsExpand
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Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.
The somatic recombination of lymphocyte antigen receptor loci is integral to lymphocyte differentiation and adaptive immunity. Here we review the relation of this highly choreographed process withExpand
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Cohesin and chromatin organisation.
Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphaseExpand
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Nuclear genetic regulation of the human mitochondrial transcriptome
Mitochondria play important roles in cellular processes and disease, yet little is known about how the transcriptional regime of the mitochondrial genome varies across individuals and tissues. ByExpand
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Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
Zbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding ourExpand
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Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
Zbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding ourExpand
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