Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
- V. Seitan, A. Faure, +10 authors M. Merkenschlager
- Biology, Medicine
- Genome research
- 1 December 2013
Chromosome conformation capture approaches have shown that interphase chromatin is partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological domains. This… Expand
A role for cohesin in T cell receptor rearrangement and thymocyte differentiation
- V. Seitan, B. Hao, +15 authors M. Merkenschlager
- Biology, Medicine
- Nature
- 10 August 2011
Cohesin enables post-replicative DNA repair and chromosome segregation by holding sister chromatids together from the time of DNA replication in S phase until mitosis. There is growing evidence that… Expand
Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance
- V. Seitan, P. Banks, +14 authors T. Strachan
- Biology, Medicine
- PLoS biology
- 4 July 2006
Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating… Expand
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin.
- Elizabeth Ing-Simmons, V. Seitan, +6 authors M. Merkenschlager
- Biology, Medicine
- Genome research
- 12 February 2015
In addition to mediating sister chromatid cohesion during the cell cycle, the cohesin complex associates with CTCF and with active gene regulatory elements to form long-range interactions between its… Expand
Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.
- V. Seitan, M. Krangel, M. Merkenschlager
- Biology, Medicine
- Trends in immunology
- 1 April 2012
The somatic recombination of lymphocyte antigen receptor loci is integral to lymphocyte differentiation and adaptive immunity. Here we review the relation of this highly choreographed process with… Expand
Cohesin and chromatin organisation.
- V. Seitan, M. Merkenschlager
- Biology, Medicine
- Current opinion in genetics & development
- 1 April 2012
Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase… Expand
Nuclear genetic regulation of the human mitochondrial transcriptome
- Aminah T Ali, Lena Boehme, G. Carbajosa, V. Seitan, K. Small, Alan Hodgkinson
- Biology, Medicine
- eLife
- 18 February 2019
Mitochondria play important roles in cellular processes and disease, yet little is known about how the transcriptional regime of the mitochondrial genome varies across individuals and tissues. By… Expand
Abstracts of the First Biennial Symposium on Regulatory T Cells and T Helper Cells. March 30, 2012. London, United Kingdom.
- V. Seitan, K. Tachibana, +4 authors M. Merkenschlager
- Medicine
- Immunology
- 2012
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
- Brooke C Wilson, Lena Boehme, +4 authors V. Seitan
- Biology, Medicine
- Nature communications
- 29 October 2020
Zbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding our… Expand
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
- Brooke C Wilson, Lena Boehme, +4 authors V. Seitan
- Biology
- 13 December 2019
Zbtb11 is a conserved transcription factor mutated in families with hereditary intellectual disability. Its precise molecular and cellular functions are currently unknown, precluding our… Expand