• Publications
  • Influence
Clinical Pharmacokinetics of Nitroprusside, Cyanide, Thiosulphate and Thiocyanate
  • V. Schulz
  • Chemistry, Medicine
  • Clinical pharmacokinetics
  • 1 May 1984
TLDR
Sodium nitroprusside decomposes within a few minutes after intravenous infusion to form metabolites which are pharmacologically inactive but toxicologically important and must be detoxified in the body into thiocyanate using thiosulphate as substrate. Expand
Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider.
  • V. Schulz
  • Medicine
  • Phytomedicine : international journal of…
  • 2003
TLDR
Given the limited therapeutic options for DAT, treatment with EGb still appears to be the method of choice compared to the ChE inhibitors, but the relatively small differences are called into question by the occurrence of drug-specific side effects with the Ch E inhibitors. Expand
Safety of St. John's Wort extract compared to synthetic antidepressants.
  • V. Schulz
  • Medicine
  • Phytomedicine : international journal of…
  • 13 February 2006
TLDR
The safety of SWE must be considered more favourable than that of synthetic antidepressants, and should be taken concurrently with other antidepressants, with coumarin-type anticoagulants, the immunosuppressants cyclosporine and tacrolimus, protease and reverse transcriptase inhibitors used in anti-HIV treatment or with certain antineoplastic agents. Expand
Cyanide toxicity of sodium nitroprusside in therapeutic use with and without sodium thiosulphate
TLDR
Pharmacokinetic calculation of the rise in cyanide level showed that mono-infusion of SNP together with thiosulphate is a procedure free of danger and should become the technique of choice when therapeutically administering SNP in order to lower blood pressure. Expand
Rational Phytotherapy: A Physicians' Guide to Herbal Medicine
TLDR
One hundred most commonly prescribed herbal medications in Germany are listed. Expand
Nitroprusside‐Induced Formation of Cyanide and Its Detoxication with Thiosulfate During Deliberate Hypotension
TLDR
It is shown that even with moderately long durations of administration (2–3 h), markedly elevated cyanide levels can result from SNP infusion rates in excess of 4–5 μg/kg/min, and an infusion of a mixture of SNP and thiosulfate reliably prevents such SNP-induced increases in cyanide Levels. Expand
Rational phytotherapy : a reference guide for physicians and pharmacists
TLDR
The aim of this study was to establish a database of herbs and phytotherapy products available in Germany and establish a chronology of their use and intended applications. Expand
Outpatient use of low molecular weight heparin (Dalteparin) for the treatment of deep vein thrombosis of the upper extremity.
TLDR
This study supports the safety and effectiveness of dalteparin in the treatment of upper extremity DVT and given that these patients were treated as outpatients, there is a potential for huge cost savings. Expand
Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?
TLDR
A preventive risk assessment for pharmacokinetic drug interactions should first be realized for synthetic drugs with a narrow therapeutic index, since herbal medicines are considered to have a broad therapeutic range. Expand
Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs.
  • V. Schulz
  • Medicine
  • Phytomedicine : international journal of…
  • 2002
TLDR
In the medically supervised treatment of mild to moderate depression, doses of approximately 500-1000 mg of extract per day of these preparations of St John's Wort are of comparable efficacy to synthetic antidepressants in their normally prescribed dosages. Expand
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