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Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
TLDR
The results suggest that marrubiin, like hydroalcoholic extract of M. vulgare, does not interact with opioid systems, and is more potent than some well-known analgesic drugs. Expand
Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae).
TLDR
Marrubiin, a furane labdane diterpene, is the main analgesic compound present in Marrubium vulgare, a medicinal plant used in Brazil and other countries to treat several ailments, suggesting its possible use as a model to obtain new and potent analgesic agents. Expand
Antioedematogenic effect of marrubiin obtained from Marrubium vulgare.
TLDR
The results demonstrate that the systemic administration of marrubiin exerts a non-specific inhibitory effect on pro-inflammatory agent-induced microvascular extravasation of Evans blue in mouse ear. Expand
Mechanisms underlying the relaxation response induced by bradykinin in the epithelium‐intact guinea‐pig trachea in vitro
TLDR
The results indicate that BK‐induced relaxation in GPT+E depends on prostanoids (probably PGE2 acting via EP3 receptors) and NO release and seems to involve complex interactions between kinin B2 receptors, COX‐2, nNOS, eNOS and tyrosine kinases. Expand
Brain activation patterns underlying fast habituation to painful laser stimuli.
TLDR
The EDA habituation profile to painful stimulation may constitute a pain-related (endo)phenotype and may be an informative additional endpoint measure in fMR-imaging of pain, especially when people suffering from chronic pain states in which pain processing is often altered are studied. Expand
Antispasmodic effects of hydroalcoholic extract of Marrubium vulgare on isolated tissues.
TLDR
The results showed that this extract exert a significant antispasmodic activity which inhibits the action of some neurotransmitters, such as acetylcholine, bradykinin, prostaglandin E(2), histamine and oxytocin, with putative selectivity for cholinergic contractions. Expand
Isolation and identification of active compounds from Drimys winteri barks.
TLDR
Compounds 1 and 2 exhibited marked antinociceptive action by intraperitoneal and oral routes against acetic acid-induced abdominal constrictions in mice, suggesting that they are responsible, at least partially, for the antinOCiceptive effects of this plant. Expand
Anti-allergic effects and oedema inhibition caused by the extract of Drymis winteri
TLDR
The results confirm and extend the previous studies, and demonstrate the clear oral anti-inflammatory and anti-allergic properties of the active principle(s) present in the barks of D. winteri, thus confirming its reported medicinal use in folk medicine for the management of airway diseases. Expand
Nitric oxide pathway‐mediated relaxant effect of bradykinin in the guinea‐pig isolated trachea
TLDR
Findings indicate that BK‐induced relaxation in guinea‐pig trachea is mediated jointly by the release of NO or a NO‐related substance and a prostanoid, probably prostaglandin E2. Expand
Analgesic profile of hydroalcoholic extract obtained from Marrubium vulgare.
TLDR
The results suggest that this hydroalcoholic extract exhibits significant analgesic activity, antagonizing chemically-induced acute pain, and may be related to the presence of steroids and terpenes, which were detected by TLC analysis. Expand
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