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Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells.
Factors secreted by macrophages contribute to whole body insulin resistance, acting in part on adipose tissue. Muscle is the major tissue for glucose disposal, but how macrophage-derived factorsExpand
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Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.
Fatty acids are a major fuel source used to sustain contractile function in heart and oxidative skeletal muscle. To meet the energy demands of these muscles, the uptake and beta-oxidation of fattyExpand
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Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.
AIMS During reperfusion of the ischaemic myocardium, fatty acid oxidation rates quickly recover, while glucose oxidation rates remain depressed. Direct stimulation of glucose oxidation via activationExpand
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Cytochrome P450‐derived eicosanoids and heart function
ABSTRACT The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of enzymes, which are important in the metabolism of foreign and endogenous compounds. CYP isoforms metabolize aExpand
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Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells
Obesity is associated with insulin resistance and increased risk for developing type 2 diabetes. Enlarged adipocytes develop resistance to the anti-lipolytic action of insulin. Elevated levels ofExpand
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Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological aging of Saccharomyces cerevisiae. Compensatory role of succinate oxidation.
We investigated oxidative processes in mitochondria of Saccharomyces cerevisiae grown on ethanol in the course of chronological aging. We elaborated a model of chronological aging that avoids theExpand
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Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.
We previously showed that genetic inactivation of malonyl-CoA decarboxylase (MCD), which regulates fatty acid oxidation, protects mice against high-fat diet-induced insulin resistance. Development ofExpand
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Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress.
Epoxyeicosatrienoic acids (EETs) are active metabolites of arachidonic acid that are inactivated by soluble epoxide hydrolase enzyme (sEH) to dihydroxyeicosatrienoic acid. EETs are known to renderExpand
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PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) areExpand
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Reserve carbohydrates maintain the viability of Saccharomyces cerevisiae cells during chronological aging
Glycogen and trehalose are well known to participate in many important cell functions, e.g., protection from stress factors, regulation of cell growth and division, spore formation. Since the agingExpand
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