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- Publications
- Influence
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
- Tanya M. Teslovich, K. Musunuru, +206 authors S. Kathiresan
- Biology, Medicine
- Nature
- 5 August 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery… Expand
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
- S. Ripke, B. Neale, +297 authors M. O’Donovan
- Biology, Medicine
- Nature
- 18 July 2014
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association… Expand
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. Speliotes, C. Willer, +372 authors R. Loos
- Biology
- 2010
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between… Expand
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- C. Willer, E. Speliotes, +142 authors J. Hirschhorn
- Biology, Medicine
- Nature Genetics
- 2009
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide… Expand
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, E. Schmidt, +256 authors G. Abecasis
- Medicine, Biology
- Nature Genetics
- 6 October 2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… Expand
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, +301 authors I. Barroso
- Biology, Medicine
- Nature Genetics
- 17 January 2010
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting… Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, +201 authors M. McCarthy
- Biology, Medicine
- Nature Genetics
- 26 July 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… Expand
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- S. Kathiresan, O. Melander, +23 authors M. Orho-Melander
- Biology, Medicine
- Nature Genetics
- 13 January 2008
Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals… Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, +442 authors T. Frayling
- Biology, Medicine
- Nature Genetics
- 8 September 2014
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… Expand
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