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Genetic studies of body mass index yield new insights for obesity biology

TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
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Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids

TLDR
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
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Biological Insights From 108 Schizophrenia-Associated Genetic Loci

TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

TLDR
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.

Discovery and Refinement of Loci Associated with Lipid Levels

TLDR
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

TLDR
Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

TLDR
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

TLDR
A meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, finds a long tail of additional common variant loci explaining much of the variation in susceptibility to type 2 diabetes.
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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and…

  • Leandra Ziad A Zargar Abdul Niveen M Benjamin Cecilia Robe Abarca-GĂłmez Abdeen Hamid Abu-Rmeileh Acosta-CazarLeandra Abarca-GĂłmez M. Ezzati
  • Medicine
    The Lancet
  • 16 December 2017
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Defining the role of common variation in the genomic and biological architecture of adult human height

TLDR
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
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