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Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.
- R. Virtanen, J. Savola, V. Saano, L. Nyman
- Chemistry, Medicine
- European journal of pharmacology
- 20 May 1988
Based on results, medetomidine can be classified as a potent, selective and specific alpha 2-adrenoceptor agonist. Expand
Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole.
- R. Virtanen, J. Savola, V. Saano
- Biology, Medicine
- Archives internationales de pharmacodynamie et de…
The results show that atipamezole is a potent, selective and specific antagonist of both centrally and peripherally located alpha 2-adrenoceptors. Expand
Medications and Chronic Diseases as Risk Factors for Falling Injuries in the Elderly
- O. Ryynänen, S. Kivelä, R. Honkanen, P. Laippala, V. Saano
- Scandinavian journal of social medicine
- 1 December 1993
The results suggest caution in the use of benzodiazepines among the elderly and show advanced age and the presence of Benzodiazepine in the serum to be independent risk factors for falling both in the men and women. Expand
Effects of felbamate on the pharmacokinetics of a low‐dose combination oral contraceptive
- V. Saano, P. Glue, +9 authors M. Affrime
- Clinical pharmacology and therapeutics
- 1 November 1995
Because of the effect of felbamate on the pharmacokinetics of gestodene and the report of intermenstrual bleeding, it is possible that the contraceptive efficacy of low‐dose combination oral contraceptives may be adversely affected during fel bamate treatment. Expand
Possible Interaction Between Oxcarbazepine and an Oral Contraceptive
The results indicate that OCBZ, like most antiepileptic drugs (AEDs), decreases the bioavailability of EE and LNG, perhaps by affecting metabolism or protein binding. Expand
Acceptability and profile of the clinical drug trials underway in Finnish university hospitals in the 1990s: applications reviewed by ethics committees.
- T. Keinonen, S. Nieminen, V. Saareks, V. Saano, P. Ylitalo
- Methods and findings in experimental and clinical…
- 1 September 2001
The findings support the opinion that the submitted documents need to be improved, especially with regard to informed consent and study protocols, in order to gain better Good Clinical Practice (GCP) compliance. Expand
Tremorigenic effect and inhibition of tryptamine and serotonin receptor binding by beta-carbolines.
- M. Airaksinen, A. Lecklin, V. Saano, L. Tuomisto, J. Gynther
- Chemistry, Medicine
- Pharmacology & toxicology
The Ki values for norharmane, harmaline and harmine for TA sites indicate the highest affinity so far described for natural beta-carbolines to any receptor sites and thus may indicate their major site of action. Expand
Pharmacokinetics of ibuprofen in man: a single-dose comparison of two over-the-counter, 200 mg preparations.
- P. Karttunen, V. Saano, P. Paronen, P. Peura, M. Vidgrén
- International journal of clinical pharmacology…
- 1 June 1990
The pharmacokinetic properties of two 200 mg, over-the-counter ibuprofen preparations were compared in a randomized crossover study on ten healthy volunteers and there was no statistically significant difference between the preparations in the bioavailability of ib uprofen. Expand
Correlation Between Ciliary Beat Frequency and the Structure of Ciliated Epithelia in Pathologic Human Nasal Mucosa
The structure and function of ciliated epithelium were studied in 44 human nasal mucosa samples using a photoelectric method and scanning electron microscopy and found to be explanatory factors accounting for the decreased ciliary activity. Expand
Binding of strychnocarpine and related β-carbolines to brain receptors in vitro
Strychnocarpine showed a low to very low affinity for all the receptors tested, which might explain part of the tremorigenic effects found earlier in the in vivo studies. Expand