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A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin.
TLDR
The data suggest that a short corticotropin test has a good prognostic value and could be helpful in identifying patients with septic shock at high risk for death.
Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies
TLDR
A mathematical model of the virus Transmission dynamics that takes into account the protective effect of ABO natural antibodies indicated that the ABO polymorphism could contribute to substantially reduce the virus transmission, affecting both the number of infected individuals and the kinetics of the epidemic.
Clinical trial: radiofrequency energy delivery in proton pump inhibitor‐dependent gastro‐oesophageal reflux disease patients
TLDR
Radiofrequency energy delivery is an endoscopic procedure developed for the treatment of gastro‐oesophageal reflux disease and has shown promising results in animals and humans.
Incidence and prognosis of sustained arrhythmias in critically ill patients.
TLDR
Sustained arrhythmias are observed in 12% of patients admitted to general ICUs, and after adjusting for prognosis factors and propensity scores, ventricular arrh rhythmias still increased mortality but supraventricular arrHythmias and conduction abnormalities did not.
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study
TLDR
The identification of CRC-predisposing combinations, composed of alleles PTGS1 c.639A, PLA2G2A c.435+230C, PPARG c.1431C, IL8 c.-352A, and MTHFR c.1286C, highlights the importance of inflammatory processes in susceptibility to sporadic CRC, as well as a possible crosstalk between inflammation and one-carbon pathways.
A Prospective Longitudinal Study of BK Virus Infection in 104 Renal Transplant Recipients
TLDR
BK virus infection during the first year after renal transplantation was studied prospectively in 104 unselected consecutive patients and the noncoding control region (NCCR) of BKV isolates was sequenced.
Sample size used to validate a scale: a review of publications on newly-developed patient reported outcomes measures
TLDR
The sample size determination for psychometric validation studies is rarely ever justified a priori, and the lack of clear scientifically sound recommendations on this topic emphasizes that existing methods to determine the sample size needed to assess the various measurement properties of interest should be made more easily available.
Prevention of acquired infections in intubated patients with the combination of two decontamination regimens
TLDR
Acquired infections were substantially reduced by mupirocin/chlorhexidine plus polymyxin/tobramycin, whereas each regimen given alone was ineffective.
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