V. Rosário

Publications51
h-index20
Citations1,971
Highly Influential Citations72
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Genetics of chloroquine resistance in malaria parasites
TLDR
It is shown that resistance to the antifolate drug pyrimethamine arises by mutation and that the genetic factors involved can undergo recombination with other markers in crosses between resistant and sensitive parasite lines.
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
TLDR
A genetic cross between CQR and chloroquine-susceptible (CQS) clones of P. falciparum indicated that the genetic locus governingchloroquine efflux and resistance is independent of the known mdr-like genes.
Co‐occurrence of East and West African kdr mutations suggests high levels of resistance to pyrethroid insecticides in Anopheles gambiae from Libreville, Gabon
Abstract.  Point mutations in the voltage‐gated sodium channel gene involved in knockdown resistance to DDT and pyrethroid insecticides have been described in several insect species. In the malaria…
Cloning of naturally occurring mixed infections of malaria parasites.
TLDR
Clones have been established from a cultured isolate of Plasmodium falciparum characterized by two electrophoretic forms of glucose phosphate isomerase that showed microscopically visible parasites after 21 days.
Male size does not affect mating success (of Anopheles gambiae in São Tomé)
TLDR
It is determined that size did not affect mating success of male Anopheles gambiae Giles sensu stricto, the main malaria vector in tropical Africa, and that larval intraspecific competition is probably insignificant in this population of An.
'A mate or a meal' – Pre-gravid behaviour of female Anopheles gambiae from the islands of São Tomé and Príncipe, West Africa
TLDR
It is suggested that insufficiency of Juvenile Hormone until the third day of adult life is responsible for gonotrophic inactivity and that by partitioning mating between the second or third day after emergence females maximise their chances of out-crossing.
A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum
Clonal diversity in a single isolate of the malaria parasite Plasmodium falciparum.
ANTIMALARIAL ACTIVITY OF SOME PLANTS TRADITIONALLY USED IN MOZAMBIQUE
TLDR
Evaluated the claimed antimalarial properties of fifty eight crude extracts from fifteen plants used in traditional medicine against malaria and fever, mainly from Southern African regions, found two of them showed a significant activity and two showed a moderate activity.
High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length…
TLDR
Analysis of populations from villages in Guinea-Bissau and in an area of high malarial transmission in Senegal demonstrated a very high prevalence of naturally acquired serum IgG responses to PF83/AMA-1, showing that PF83-7G8-1 may be a well-recognized asexual parasite antigen.
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