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Snake Venom L-Amino Acid Oxidases: Trends in Pharmacology and Biochemistry
TLDR
This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far. Expand
Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management.
TLDR
The results revealed that both antivenoms exhibit impaired immunoreactivity towards crotamine and display restricted recognition of PLA(2) molecules from C. durissus subspecies populations, supporting the view that these taxa can be considered geographical variations of the same species. Expand
Structural and functional characterization of neuwiedase, a nonhemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom.
A fibrino(geno)lytic nonhemorrhagic metalloprotease (neuwiedase) was purified from Bothrops neuwiedi snake venom by a single chromatographic step procedure on a CM-Sepharose column. NeuwiedaseExpand
Biochemical and functional characterization of an L-amino acid oxidase isolated from Bothrops pirajai snake venom.
TLDR
BpirLAAO-I is a multifunctional protein with promising biotechnological and medical applications that induces time-dependent platelet aggregation, mouse paw edema, cytotoxic activity against Escherichia coli and tumor cells, and also a typical fago (M13mp18) DNA fragmentation. Expand
Combined snake venomics and venom gland transcriptomic analysis of Bothropoides pauloensis.
TLDR
Data support the view that venom composition is influenced by transcriptional and translational mechanisms and emphasize the value of combining proteomic and transcriptomic approaches to acquire a more complete understanding of the toxinological profile and natural history of the snake venom. Expand
Structural and functional properties of Bp-LAAO, a new L-amino acid oxidase isolated from Bothrops pauloensis snake venom.
TLDR
Structural and phylogenetic studies identified residues under positive selection and their probable location in Bp-LAAO and other snake venom LAAOs (svLAAOs) and structural and functional investigations of these enzymes can contribute to the advancement of toxinology and to the elaboration of novel therapeutic agents. Expand
Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.
Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regardingExpand
Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.
TLDR
BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom, was structurally and functionally characterized and displayed bactericidal activity and promoted the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Expand
A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic activity.
TLDR
M-VI was devoid of phospholipase A2 (PLA2) activity on egg yolk, but could induce drastic necrosis on skeletal muscle fibres as well as rapid and transient edema on the rat paw, and revealed high homology with other Lys 49 PLA2-like myotoxins from other bothropic venoms. Expand
Purification and partial characterization of a new proteolytic enzyme from the venom of Bothrops moojeni (CAISSACA).
A basic serine protease which is active on casein and fibrinogen was purified from Bothrops moojeni venom using a single step chromatography on a CM-Sepharose fast flow column. The enzyme, MOO3, wasExpand
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