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The utility of sulfonate salts in drug development.
This review sets out to define some of the advantages provided through utilization of sulfonic acids, explaining the importance of their retention as part of a thorough salt selection process. Expand
Metabolism of 1-(0-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in rats.
The metabolism of 14C-labeled 1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in rats was investigated. Metabolites were identified in feces and urine extracts by thin-layter chromatography (TLC),Expand
Aromatic hydroxylation and alkyl oxidation in metabolism of mitotane (o,p'-DDD) in humans.
Abstract: Ether extracts of urine from patients treated with mitotane (o,p'-DDD) were methylated with diazomethane. Five derivatives of metabolites were detected and identified by comparison of GLCExpand
Chromatographic assays for folic acid.
TLC and high-pressure liquid chromatographic (HPLC) assays for folic acid were developed and a direct colorimetric method gave precise, but unspecific, results, while the USP XIX colorIMetric method lacked both precision and specificity. Expand
Determination of isepamicin sulfate and related compounds by high performance liquid chromatography using evaporative light scattering detection.
A simple reversed phase high performance liquid chromatographic method was developed for the analysis of isepamicin sulfate using the use of evaporative light scattering detection and the specificity, assay linearity, low level assaylinearity and assay repeatability were investigated. Expand
Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation
Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence ofExpand
Development and validation of an automated static headspace gas chromatography-mass spectrometry (SHS-GC-MS) method for monitoring the formation of ethyl methane sulfonate from ethanol and methane
An automated sample preparation and analysis procedure was developed to monitor the formation of ethyl methane sulfonate from reaction mixtures containing ethanol and methane sulfonic acid, achieving excellent linearity, repeatability and robustness, allowing the system to be used in kinetic studies. Expand
A Detailed Study of Sulfonate Ester Formation and Solvolysis Reaction Rates and Application toward Establishing Sulfonate Ester Control in Pharmaceutical Manufacturing Processes
Sulfonate esters of lower alcohols possess the capacity to react with DNA and cause mutagenic events, which in turn may be cancer inducing. Consequently, the control of residues of such substances inExpand
PQRI recommendations on particle-size analysis of drug substances used in oral dosage forms.
This document provides information for the Pharmaceutical Industry and the Federal Drug Administration (FDA) regarding the selection of suitable particle-size analysis techniques, development andExpand
Determination of enantiomers in a synthetic argininal peptide using capillary zone electrophoresis and high-performance liquid chromatography.
Capillary zone electrophoresis (CZE) and reversed-phase high-performance liquid chromatographic (HPLC) methods were developed to separate and quantitate the enantiomers in SCH 201781 and were shown to be precise and reproducible. Expand