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Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
TLDR
Three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C, showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.
Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest.
TLDR
Bioassay-guided fractionation of methanolic extracts of Mundulea chapelieri resulted in the isolation of two new flavonoids, isomundulinol and 3-deoxy-MS-II, which were tested for cytotoxicity against the A2780 human ovarian cancer cell line.
Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest.
TLDR
A bioassay-guided fractionation of the EtOH extract of the Madagascan plant Terminalia calcicola led to the isolation of two new cytotoxic xanthones, termicalcicolanone A andtermicalcIColanone B, which showed modest antiproliferative activity toward the human ovarian cancer cell line.
Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.
Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These
Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1
TLDR
A structure–activity relationship study suggested that the presence of an α,β-unsaturated carbonyl moiety is not essential for potent antimalarial activity.
Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest.
Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the small twigs of Brachylaena ramiflora var. ramiflora resulted in the isolation of the two new triterpene esters 1 and 2 and five known
Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest.
TLDR
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boiv inides 1-6, which showed significant antiproliferative activity against the A2780 human ovarian cancer cell line.
Antiproliferative compounds of Artabotrys madagascariensis from the Madagascar rainforest
TLDR
Two of the isolates, melodor inol and acetylmelodorinol, were found to display antiproliferative activity against five different tumour cell lines with IC50 values ranging from 2.4 to 12 µM.
Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
TLDR
Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridOCarpusic acids A-E (1-5), which established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation the structures of the new compounds 1-5.
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1
TLDR
Three new lignans isolated from Cleistanthus boivinianus showed potent antiproliferative activities against the A2780 ovarian cancer cell line, and compounds 1, 4, and 5 showed potent antimicrobial activity against the HCT-116 human colon carcinoma cell line.
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