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IFN-β Inhibits Human Th17 Cell Differentiation1
IFN-β-1a has been used over the past 15 years as a primary therapy for relapsing-remitting multiple sclerosis (MS). However, the immunomodulatory mechanisms that provide a therapeutic effect againstExpand
Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes
Statins, extensively used as cholesterol-lowering agents, have recently been identified as immunomodulatory agents. This study investigated the statins’ mechanisms that target the autoimmune responseExpand
LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation1
Lymphokine gene expression is a precisely regulated process in T cell-mediated immune responses. In this study we demonstrate that engagement of the β2 integrin LFA-1 in human peripheral T cellsExpand
B Cells as a Therapeutic Target for IFN-β in Relapsing–Remitting Multiple Sclerosis
IFN-β-1b is a first-line immunomodulatory therapy for relapsing–remitting multiple sclerosis (RR MS). However, its effects on B cells have not been characterized. In vitro studies of B cells derivedExpand
Cytokines and cardiovascular disease
The role of cytokines in the pathogenesis of cardiovascular disease is increasingly evident since the identification of immune/inflammatory mechanisms in atherosclerosis and heart failure. In thisExpand
Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys.
PURPOSE AAV vectors produce stable transgene expression and elicit low immune response in many tissues. AAVs have been the vectors of choice for gene therapy for the eye, in particular the retina.Expand
Interferon-beta inhibits Th17 cell differentiation in patients with multiple sclerosis.
Interferon-beta (IFNbeta) has been used over the past 15 years as a first-line therapy for relapsing remitting multiple sclerosis (RR MS), however its mechanisms of action are still not completelyExpand
Regulation of Suppressors of Cytokine Signaling as a Therapeutic Approach in Autoimmune Diseases, with an Emphasis on Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating, presumably autoimmune disease of the central nervous system (CNS). Among the available MS therapies, interferon (IFN)β and the recentlyExpand
Inflammatory mechanisms in vascular disease
Mechanisms have been identified by which the vasculature modifies lipids into an atherogenic form, with those modified lipids in turn activating vascular and immune cells, initiatingExpand
Traditional Chinese medicines as immunosuppressive agents.
INTRODUCTION Traditional Chinese Medicines (TCM) have been used for centuries in China to treat various immune-mediated disorders. METHODS This review focuses on the clinical and experimentalExpand