• Publications
  • Influence
Pathway analysis of genomic data: concepts, methods, and prospects for future development.
Genome-wide data sets are increasingly being used to identify biological pathways and networks underlying complex diseases. In particular, analyzing genomic data through sets defined by functionalExpand
  • 251
  • 13
  • PDF
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in Alzheimer’s disease (AD) pathogenesis with a significant genetic contribution. Molecular imaging can provide anExpand
  • 153
  • 9
Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.
  • V. Ramanan, A. Saykin
  • Biology, Medicine
  • American journal of neurodegenerative disease
  • 18 September 2013
The discovery of causative genetic mutations in affected family members has historically dominated our understanding of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson'sExpand
  • 153
  • 6
  • PDF
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
The Genetics Core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI), formally established in 2009, aims to provide resources and facilitate research related to genetic predictors ofExpand
  • 115
  • 4
  • PDF
Protective variant for hippocampal atrophy identified by whole exome sequencing
We used whole‐exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in‐silico predicted missense variant inExpand
  • 48
  • 3
  • PDF
GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.
Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide association study ofExpand
  • 79
  • 2
  • PDF
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment
Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the apolipoprotein E (APOE) ɛ4 alleleExpand
  • 69
  • 2
  • PDF
Genome-wide pathway analysis of memory impairment in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks
Memory deficits are prominent features of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The genetic architecture underlying these memory deficits likely involves the combined effectsExpand
  • 63
  • 2
  • PDF
Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults.
Depressive symptoms are common in older adults and are particularly prevalent in those with or at elevated risk for dementia. Although the heritability of depression is estimated to be substantial,Expand
  • 28
  • 2
  • PDF
Gene-based GWAS and biological pathway analysis of the resilience of executive functioning
Resilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previouslyExpand
  • 28
  • 2
  • PDF
...
1
2
3
4
...