Share This Author
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.
For the first time, a highly active and stable nucleoside triphosphate mimic has been identified, which is potentially useful as a new type of antiviral drug.
Inhibition of Measles Virus Replication by 5′-Nor Carbocyclic Adenosine Analogues
- D. Barnard, V. D. Stowell, R. Sidwell
- Chemistry, BiologyAntiviral chemistry & chemotherapy
- 1 August 2001
Results suggest that these compounds may be clinically useful anti-MV virus agents, and those either unsubstituted at C4 or possessing a hydroxyl, azido or amino substituent at that position were the most active.
The enantiomers of carbocyclic 5'-norguanosine: activity towards Epstein-Barr virus.
PENTAFLUOROPHENOL : A SUPERIOR REAGENT FOR CONDENSATIONS IN HETEROCYCLIC CHEMISTRY
Abstract The use of pentafluorophenol as a superior reagent for heterocyclic condensations, where other traditional condensing agents such as DCC and CDI failed, has been demonstrated.
Analogues of azepinomycin as inhibitors of guanase.
Compound 6-amino-5,6,7,8,-tetrahydro-4H-imidazo[4,5-e][1,4]diazepine- 5,8-dione was synthesized and screened against rabbit liver guanase and both were found to be moderate inhibitors of the enzyme with K's in the range of 10(-4) M.
Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5:7-fused, planar, aromatic heterocyclic ring system.
Investigations into biochemical mode of inhibition of guanase by azepinomycin: synthesis and biochemical screening of several analogues of azepinomycin.
The results suggest that while the 6-hydroxy group of azepinomycin is crucial for activity, its putative transition state mode of inhibition of guanase is questionable, and the additional H-bonding sites and hydrophobic groups appear to be tolerated, and may in fact enhance the potency of inhibition.
Synthesis of Azole Nucleoside 5′‐Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases
- Guangyi Wang, K. Sakthivel, P. D. Cook
- Chemistry, BiologyNucleosides, nucleotides & nucleic acids
- 1 January 2004
A series of azole nucleoside 5′‐MP mimics (P1Ms) based on ribavirin, EICAR and bredinin were synthesized and screened against human and C. albicans IMP dehydrogenises, demonstrating substantial IMPDH inhibition with Ki values in low micromolar range.
A PROTECTED FORM OF (1S,2R,3S,4R)-4-AMINOCYCLOPENTANE-1,2,3-TRIOL, A USEFUL PRECURSOR TO 5′-NOR CARBOCYCLIC NUCLEOSIDES
5′-Nor carbocyclic nucleosides have been found to possess a variety of meaningful biological properties. One of the building blocks for this class of compounds is…