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Mutagenicity of nitroaromatic compounds.
Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage*
TLDR
The Ile mutation at position 184 with a longer and more rigid β-branched side chain, which was previously known to alter the RT-template interaction, also appears to deform the shape of the dNTP binding pocket, which can restrict ground state dNTB binding and lead to inefficient DNA synthesis particularly at low dN TP concentrations. Expand
Use of 2-aminopurine fluorescence to examine conformational changes during nucleotide incorporation by DNA polymerase I (Klenow fragment).
We have investigated conformational transitions in the Klenow fragment polymerase reaction by stopped-flow fluorescence using DNA substrates containing the fluorescent reporter 2-aminopurine (2-AP)Expand
Evidence That HIV-1 Reverse Transcriptase Employs the DNA 3′ End-directed Primary/Secondary RNase H Cleavage Mechanism during Synthesis and Strand Transfer*
TLDR
Overall, results indicate RT can catalyze pause-associated DNA 3′ end-directed primary and secondary cuts during synthesis and these cuts can contribute to strand transfer by creation of an invasion site. Expand
Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages*
TLDR
A role for NC and other factors that enhance DNA synthesis in the prevention of RNase H cleavages that could be detrimental to viral replication is revealed. Expand
Photoassisted catalytic oxidation of alcohols and halogenated hydrocarbons with amorphous manganese oxides
Abstract This manuscript discusses the synthesis of Amorphous Manganese Oxide (AMO) materials that are used for efficient photoassisted catalytic oxidation of alcohols and halogenated hydrocarbons.Expand
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
TLDR
UvrA recognizes conformational changes induced by structurally different lesions and that in certain cases the binding affinities of UvrA and UvrB can be correlated with the incision rates, and a particularly noteworthy finding is that UvrABC repair of a substrate with no base opposite C8-AP-dG was quite inefficient as compared to the same adduct with a C opposite it. Expand
Synthesis and characterization of oligodeoxynucleotides containing the major DNA adducts formed by 1,6- and 1,8-dinitropyrene.
TLDR
The N-hydroxyaminonitropyrene, generated in situ from each nitrosonitroprene, was used successfully to introduce the dinitropyrene-derived DNA adduct at a defined site in an oligonucleotide. Expand
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