• Publications
  • Influence
Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions.
The development of new "atypical" antipsychotic agents, which are safer than classical neuroleptics and also active against the negative symptoms and neurocognitive deficits caused by the illness,Expand
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High-performance liquid chromatographic determination of Levetiracetam in human plasma: comparison of different sample clean-up procedures.
An accurate and precise high-performance liquid chromatographic method using diode array detection for the determination of the novel antiepileptic, Levetiracetam, has been developed. Three clean-upExpand
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Quality control of commercial tablets containing the novel antipsychotic quetiapine.
Quetiapine (bis [2-(2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl]ethoxy)ethanol]fumarate) is the most recent agent introduced on the drug market for the treatment of psychotic disorders. Two differentExpand
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Enantioselective determination of the novel antidepressant mirtazapine and its active demethylated metabolite in human plasma by means of capillary electrophoresis.
Mirtazapine is a recent noradrenergic and specific serotonergic antidepressant drug. A capillary electrophoretic method has been developed for the enantioseparation and analysis of mirtazapine andExpand
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Analysis of lamotrigine and its metabolites in human plasma and urine by micellar electrokinetic capillary chromatography
A reliable micellar electrokinetic capillary chromatographic method was developed and validated for the determination of lamotrigine and its metabolites in human plasma and urine. The variation ofExpand
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2013 White Paper on recent issues in bioanalysis: 'hybrid'--the best of LBA and LCMS.
The 2013 7th Workshop on Recent Issues in Bioanalysis was held in Long Beach, California, USA, where close to 500 professionals from pharmaceutical and biopharmaceutical companies, CROs andExpand
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Comparison of three analytical methods for quality control of clozapine tablets.
Three different analytical methods for the quality control of clozapine in commercial formulations were developed and compared: a liquid chromatographic (LC) method with UV detection, a capillaryExpand
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Merck's perspective on the implementation of dried blood spot technology in clinical drug development - why, when and how.
This paper communicates Merck's thoughts on why, when and how to use dried blood spot (DBS) technology in a clinical setting, and provides a strategic approach, emphasizing the necessary steps, for successful clinical implementation of this microsampling technique. Expand
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Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis.
Two antipsychotic drugs (clozapine and loxapine) and six metabolites, N-demethylclozapine, clozapine N-oxide, N-demethylloxapine (amoxapine), 7-hydroxyloxapine, 8-hydroxyloxapine, 8-hydroxyamoxapine,Expand
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Enantiomeric separation of citalopram and its metabolites by capillary electrophoresis
A simple and fast capillary electrophoretic method has been developed for the enantioselective separation of citalopram and its main metabolites, namely N‐desmethylcitalopram andExpand
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