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European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas.
TLDR
The guideline offers recommendations for patients who recurred after temozolomide treatment, for those who did not respond to temozoomide and for patients with systemic metastasis, which focused primarily on first- and second-line treatment in aggressive pituitary tumours and carcinomas.
The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.
TLDR
The abnormal expression and subcellular localization of AIP in sporadic pituitary adenomas indicate deranged regulation of this protein during tumorigenesis.
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia.
TLDR
Two novel somatic gain-of-function mutations in the gene encoding hypoxia-inducible factor 2α (HIF2A) in two patients presenting with paraganglioma and somatostatinoma, both of whom had polycythemia are reported.
The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease.
TLDR
USP8 is frequently mutated in adenomas causing Cushing's disease, especially in those from female adult patients diagnosed at a younger age.
Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa.
TLDR
Ghrelin is unlikely to be effective as a single appetite stimulatory treatment for patients with AN, and the results suggest that AN patients are less sensitive to ghrelin in terms of GH response and appetite than healthy controls.
Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine.
TLDR
The long-acting dopamine agonist BC, by increasing dopaminergic tone, may influence body weight composition in likely bodyprolinemia in patients with prolactinomas treated with the long- acting dopamine agonists bromocriptine.
Treatment of aggressive pituitary tumours and carcinomas: results of a European Society of Endocrinology (ESE) survey 2016.
TLDR
This survey confirms that TMZ is established as first-line chemotherapeutic treatment of APT/PC and the limited long-term effect of TMZ and the poor efficacy of other drugs highlight the need to identify additional effective therapies.
Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma.
TLDR
The major mechanisms that reinforced obesity were hypothalamic damage causing disrupted or impaired sensitivity to feeding-related signals for leptin, insulin, and ghrelin, and reductions in both BMR and physical activity.
Leptin and the Pituitary
TLDR
Clinically based evidence from studies performed in patients harboring different functional pituitary tumors causing a state of hormonal hypersecretion (acromegaly, prolactinomas, Cushing's disease) or hypopituitarism, are in favor of a paracrine/autocrine role of the pituitaries.
High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome.
TLDR
A high prevalence of hypopituitarism after recovery from HFRS is identified, with magnetic resonance imaging revealing atrophic pituitary and empty sella.
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