V. Pirrotta

Publications187
h-index71
Citations18,076
Highly Influential Citations1,118
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Comprehensive analysis of the chromatin landscape in Drosophila
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we… Expand
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Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites
Enhancer of Zeste is a Polycomb Group protein essential for the establishment and maintenance of repression of homeotic and other genes. In the early embryo it is found in a complex that includes ESC… Expand
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Role of the polycomb protein EED in the propagation of repressive histone marks
Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its… Expand
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing. PcG proteins regulate homeotic genes in flies and… Expand
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Polycomb silencing mechanisms and the management of genomic programmes
Polycomb group complexes, which are known to regulate homeotic genes, have now been found to control hundreds of other genes in mammals and insects. First believed to progressively assemble and… Expand
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Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
TLDR
Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. Expand
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A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.
Segmentation genes provide the signals for the activation and regulation of homeotic genes in Drosophila but cannot maintain the resulting pattern of expression because their activity ceases halfway… Expand
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Vectors for P-mediated transformation in Drosophila.
Publisher Summary Many naturally occurring Drosophila strains (P strains) contain P transposable elements that are relatively stable within that strain but transpose at a high frequency when… Expand
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Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.
Polycomb group genes are necessary for maintaining homeotic genes repressed in appropriate parts of the body plan. Some of these genes, e.g. Psc, Su(z)2 and E(z), are also modifiers of the… Expand
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Alternative Epigenetic Chromatin States of Polycomb Target Genes
Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switch… Expand
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