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Isolation of steroidal sapogenins implicated in experimentally induced cholangiopathy of sheep grazing Brachiaria decumbens in Brazil.
The analysis of the B decumbens samples by acidic hydrolysis followed by TLC and infrared spectrum revealed diosgenin as the principal sapogenin present in the plant. Expand
Experimentally Induced Cholangiohepatopathy by Dosing Sheep with Fractionated Extracts from Brachiaria Decumbens
Cholangiohepatopathy was induced in 5 lambs by oral administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout theExpand
Saponins and Sapogenins from Brachiaria decumbens Stapf
Four steroidal saponins and three sapogenins were identified from aerial parts of Brachiaria decumbens. Their structures were established by chemical and spectroscopic means (1H and 13C NMR, HMBC,Expand
Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.
From the leaves of Ilex affinis and Ilex buxifolia, two adulterant species of "erva mate" (Ilex paraguariensis), three new triter penoid glycosides were isolated and the in vitro antitrypanosomal activity of some Ilex triterpenoids is reported. Expand
Constituents from leaves of Quillaja brasiliensis
A new abietane diterpene, the 19-O-β-d-glucopyranoside of 16-hydroxylambertic acid was isolated from the leaves of Quillaja brasiliensis together with a known prosapogeninExpand
Saponins from Ilex dumosa, an Erva-maté (Ilex paraguariensis) Adulterating Plant
Extraction of Ilex dumosa leaves, a material frequently used for the adulteration of erva-mate, resulted in the isolation ofExpand
Triterpenoids from Brazilian Ilex Species and Their in Vitro Antitrypanosomal Activity
The observed results confirm the structural specificity of the I. paraguariensis triterpenoids and reinforce a previous proposal to detect mate adulteration by triter penoid analysis. Expand
Antithrombotic effect of the type III collagen-related octapeptide (KOGEOGPK) in the mouse.
A substantial contribution of platelet interactions with the type III collagen-related KOGEOGPK sequence in thrombus formation in vivo with preferential involvement in arterial thrombosis is demonstrated. Expand
Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes
It is shown that new substituted calix[4]arene podands bearing two aspartic/glutamic acid, ornithine groups or hydrazide function at the lower rim, designed as potential iron chelators could open the way to new valuable medicinal chemistry scaffolding. Expand