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The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis*
It is shown that Tat Ug05RP is more efficient than Tat Ug11LTS in its trans-activational role and in inducing apoptosis in binding tubulin via the mitochondrial pathway and the glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells. Expand
Binding of ATP to Heat Shock Protein 90
Results clearly demonstrate that hsp90 possesses a second ATP-binding site located on the C-terminal part of the protein and suggest allosteric interaction between N- and C-Terminal domains of hSp90. Expand
Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules
The results indicate that the sole phosphorylation at the AT8/AT180 epitopes, although leading to a functional defect for Tau, is not sufficient for its dissociation from the MT surface and subsequent aggregation as observed in AD. Expand
Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells
A discrete Tau–MT interaction is identified, by FRET and FRAP, in which Tau could induce conformational changes of MTs, favoring recovery of MT self-assembly. Expand
HIV-1 Tat protein enhances Microtubule polymerization
It is demonstrated that Tat could also directly trigger the mitochondrial pathway to induce T cell apoptosis, as shown in vitro by the release of cytochrome c from isolated mitochondria. Expand
Tau antagonizes end-binding protein tracking at microtubule ends through a phosphorylation-dependent mechanism
The inhibiting activity of tau on EB properties is regulated by tau phosphorylation, and the interplay between EBs and tau proteins results in modulation of microtubule dynamics. Expand
Apo‐Hsp90 coexists in two open conformational states in solution
This work has shown that Hsp90 conformational changes are driven by nucleotide‐binding‐dependent changes and not by the presence of prokaryotic homologue proteins, as previously reported in this work. Expand
New insights into the antibacterial mechanism of action of squalamine.
New insights into the mechanism of action of squalamine highlight the importance of aminosterols in the design of a new class of antibacterial compounds that could be used as disinfectants and detergents. Expand
Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers*
Analytical ultracentrifugation and binding measurements show that tubulin-stathmin associations and binding of ligands are thermodynamically independent from one another, irrespective of tubulin being bound to GTP or GDP. Expand
Interaction of 4-arylcoumarin analogues of combretastatins with microtubule network of HBL100 cells and binding to tubulin.
The synthesis of different 4-arylcoumarin analogues of combretastatin A-4 led to the identification of two new compounds (1 and 2) with potent cytotoxic activity on a CEM leukemia cell line and aExpand