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Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory.
- V. Petkov, D. Yonkov, +4 authors I. Todorov
- Psychology, Medicine
- Acta physiologica et pharmacologica Bulgarica
It has been found that Rhodiola extract in a single dose of 0.10 ml per rat essentially improves learning and retention after 24 hours and significant improvement of the long-term memory is also established in memory tests after 10-day treatment with the same dose of the extract. Expand
Pharmacological studies on substances of plant origin with coronary dilatating and antiarrhythmic action.
The results of these studies suggest that oleuropein, the valepotratic fraction, carataemon, hyperoside, and peucordin produce a clear-cut coronary dilatory action. Expand
[Lipid peroxidation changes in the brain in fetal alcohol syndrome].
- V. Petkov, D. Stoianovski, V. Petkov, Iu Vyglenova
- Biology, Medicine
- Biulleten' eksperimental'noi biologii i meditsiny
- 1 May 1992
The concentration of fluorescent products in the brain structures of rats treated perinatally with ethanol was several-fold increased as compared with controls and the levels of diene conjugates were increased in most brain structure of rats with FAS. Expand
Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.
- B. Kenarova, H. Neychev, C. Hadjiivanova, V. Petkov
- Biology, Medicine
- Japanese journal of pharmacology
Ginsenoside Rg1 induced an augmentation of the production of IL-1 by macrophages and exerted a direct mitogenic effect on microcultured thymus cells, and partly restored the impaired immune reactivity by cyclophosphamide treatment. Expand
Age-related changes in brain neurotransmission.
In experiments on 2-, 10- and 22-month-old rats it was found that the Bmax values of dopamine, serotonin, serotonin and enkephalin receptors as well as the 5-HT level in the three brain regions decreased with age. Expand
Effects of standardized ginseng extract on learning, memory and physical capabilities.
The results show that ginseng at appropriate doses improves learning, memory and physical capabilities. Expand
Age-related changes in brain biogenic monoamines and monoamine oxidase.
In 22-month old rats the levels of dopamine (DA), noradrenaline (NA) and serotonin (5-HT) markedly declined in most of the brain structures studied, but the NA level in the striatum of 22- Month old rats was increased as compared to that in 2- month old rats. Expand
Asymmetry in behavioral responses to cholecystokinin microinjected into rat nucleus accumbens and amygdala
CCK-8 exerted a favorable effect on learning and memory when injected into the left but not into the right amygdala, and increased locomotion at the lowest dose, while at the high doses it significantly decreased it. Expand
Participation of different 5-HT receptors in the memory process in rats and its modulation by the serotonin depletor p-chlorophenylalanine.
- V. Petkov, S. Belcheva, E. Konstantinova, R. Kehayov
- Chemistry, Medicine
- Acta neurobiologiae experimentalis
The memory effects of agonists and antagonists of some serotonin (5-HT) receptor subtypes were examined in experiments on rats using an active avoidance method (shuttle-box); the results obtained show different participation of 5-HT1A, 5- HT2 and 4-HT3 receptors in the mechanisms of the memory process; the nature of this involvement is modulated by the brain level of serotonin. Expand
Plants and hypotensive, antiatheromatous and coronarodilatating action.
- V. Petkov
- The American journal of Chinese medicine
These studies cover a number of plants growing in Bulgaria that have a healing effect in hypertension, atherosclerosis and ischemic heart disease according to the data of traditional medicine and conventional experimental methods in pharmacology are often unsuitable for revealing the real biological activity of one or another medicinal plant. Expand