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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.
- V. Perkovic, M. Jardine, +21 authors K. Mahaffey
- The New England journal of medicine
- 14 April 2019
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose… Expand
Worldwide access to treatment for end-stage kidney disease: a systematic review
BACKGROUND End-stage kidney disease is a leading cause of morbidity and mortality worldwide. Prevalence of the disease and worldwide use of renal replacement therapy (RRT) are expected to rise… Expand
Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial
Importance Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited… Expand
Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes.
- T. Ninomiya, V. Perkovic, +16 authors J. Chalmers
- Medicine, Computer Science
- Journal of the American Society of Nephrology…
- 1 August 2009
There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR) are separate and independent risk factors for cardiovascular and renal events among individuals with type 2… Expand
Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
BACKGROUND Several clinical trials have reported inconsistent findings for the effect of fibrates on cardiovascular risk. We undertook a systematic review and meta-analysis to investigate the effects… Expand
Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies.
- S. White, V. Perkovic, +8 authors R. Huxley
- American journal of kidney diseases : the…
- 1 August 2009
BACKGROUND There has been considerable interest in the hypothesis that low birth weight may be a marker of impaired nephrogenesis and that this is causally related to chronic kidney disease (CKD). … Expand
Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis.
BACKGROUND In patients with type 2 diabetes, sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to reduce glucose concentrations, blood pressure, and weight, but to increase LDL cholesterol… Expand
Linagliptin Lowers Albuminuria on Top of Recommended Standard Treatment in Patients With Type 2 Diabetes and Renal Dysfunction
- P. Groop, M. Cooper, V. Perkovic, A. Emser, H. Wörle, M. von Eynatten
- Diabetes Care
- 11 September 2013
OBJECTIVE Preclinical data suggest that linagliptin, a dipeptidyl peptidase-4 inhibitor, may lower urinary albumin excretion. The ability of linagliptin to lower albuminuria on top of… Expand
Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.
- K. Chan, R. Giugliano, +6 authors J. Piccini
- Journal of the American College of Cardiology
- 21 June 2016
Nonvitamin K-dependent oral anticoagulant agents (NOACs) are currently recommended for patients with atrial fibrillation at risk for stroke. As a group, NOACs significantly reduce stroke,… Expand
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials.
- V. Perkovic, D. de Zeeuw, +8 authors B. Neal
- The lancet. Diabetes & endocrinology
- 1 September 2018
BACKGROUND In the Canagliflozin Cardiovascular Assessment Study (CANVAS) Program, canagliflozin reduced the rates of major adverse cardiovascular events and the results suggested a renal benefit in… Expand