• Publications
  • Influence
Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging
TLDR
This review highlights the key achievements that have contributed to elucidating the mechanisms pertaining to vascular dysfunction in the apoE-/- mouse and discusses the main mechanisms underlying the endothelial dysfunction of conducting vessels and resistance vessels. Expand
Evaluation of baroreflex control of heart rate in renovascular hypertensive mice.
TLDR
Evaluation of autonomic control of HR showed an increased sympathetic tone and a tendency to a decreased vagal tone in 2K1C mice compared with that in sham mice, and the baroreflex sensitivity was greatly decreased. Expand
Probiotics as Beneficial Dietary Supplements to Prevent and Treat Cardiovascular Diseases: Uncovering Their Impact on Oxidative Stress
TLDR
The importance of maintaining the balance of the intestinal microbiota to prevent or combat such processes as arterial hypertension or endothelial dysfunction, which underlie many cardiovascular disorders, is reviewed and how the consumption of probiotics can improve autonomic control of cardiovascular function and provide beneficial effects in patients with heart failure is reviewed. Expand
Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
TLDR
The apolipoprotein E-deficient mouse has been the most widely used animal model of atherosclerosis because it rapidly develops severe hypercholesterolemia and spontaneous atherosclerotic lesions similar to those observed in humans. Expand
Cardiovascular Neural Reflexes in L-NAME–Induced Hypertension in Mice
TLDR
Enhancement of baroreflex sensitivity and attenuation of BJR and chemoreflex seem to be mainly caused by inhibition of NO synthesis because individual analyses did not show positive correlation between changes in these reflexes and MAP levels in the HT group. Expand
Evaluation of Vascular Function in Apolipoprotein E Knockout Mice With Angiotensin-Dependent Renovascular Hypertension
TLDR
In C57–2K1C mice, the increased reactivity to NE and the decreased endothelium-dependent relaxation contribute to the maintenance of hypertension, and the concurrence of both pathophysiologies does not result in additive effects on the vascular function. Expand
Overexpression of eNOS prevents the development of renovascular hypertension in mice.
TLDR
The data indicate that eNOS overexpression was able to prevent the development of 2K1C renovascular hypertension in mice, without affecting other characteristic cardiovascular dysfunctions. Expand
Cardiovascular Autonomic Imbalance and Baroreflex Dysfunction in the Apolipoprotein E-deficient Mouse
TLDR
An overview of abnormalities of the parasympathetic and sympathetic nervous systems controlling heart rate and blood pressure and how this dysfunction is influenced by nitric oxide, reactive oxygen species, aging and an atherogenic diet in the apoE-/-mouse is provided. Expand
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
TLDR
A novel mechanism was identified whereby chronic increases in oxidative stress, produced by mitochondrial SOD deficiency, impair vascular function via a hydrogen peroxide-dependent, COX1- dependent, endothelium-derived contracting factor through manganese superoxide dismutase. Expand
Decreased baroreflex sensitivity in isoproterenol-treated mice with cardiac hypertrophy
TLDR
In conclusion, beta-adrenoceptor-induced cardiac hypertrophy in mice led to impaired sensitivity of the cardiac baroreflex, which could be due to a diminished vagal activity to the heart. Expand
...
1
2
3
...