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[The catabolism of polyamines].
The important role of the natural polyamines putrescine, spermidine and spermine in the normal and pathological cell growth is the main reason for the active investigation of their metabolism. TheExpand
The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives.
  • P. Lin, V. Pavlov
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 17 July 2000
The increased content of nitrogen atoms in the linker chain of BNIPSpd and BNIPOPut significantly improved their aqueous dissolution properties with a marginal decrease in their cytotoxic activity. Expand
Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives.
The results obtained suggest that the cytotoxic activity of the bis-naphthalimidopropyl polyamines may be in part, caused by their effects on DNA. Expand
Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells.
Data demonstrate that the novel oxa-polyamine derivative compound 1 has considerable cytotoxic activity towards MCF-7 cells and indicate that an induction of PAO may be involved in its cytotoxicity and apoptotic effects. Expand
Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives
The data show that these novel sulphonamido oxa-polyamine derivatives possess high cytotoxic activity against MCF-7 cells and indicate that induction of PAO may mediate their cytotoxicity via apoptosis, and show that the intracellular polyamine content was only marginally reduced in response to drug treatment. Expand
Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver
The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation ofpolyamine concentrations in rat uterus by the female sex hormones. Expand
The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues.
A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated and showed the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity. Expand
Androgenic sensitivity of polyamine-oxidizing enzyme activities in female rat tissues
The effects observed suggest a possible role for testosterone in the modulation of polyamine levels in the female organs studied and especially in uterus. Expand