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A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein
TLDR
A phage K gene that encodes a protein associated with the phage tail-associated muralytic enzyme (TAME) shows bactericidal activity against globally prevalent antibiotic resistant clinical isolates of S. aureus and against the genus Staphylococcus in general. Expand
Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection
TLDR
A recombinant endolysin-deficient staphylococcal phage has been developed that is lethal to methicillin-resistant S. aureus without causing bacterial cell lysis. Expand
Antistaphylococcal activity of bacteriophage derived chimeric protein P128
TLDR
The novel chimeric protein P128 is a staphylococcal cell wall-degrading enzyme under development for clearance of S. aureus nasal colonization and MRSA infection. Expand
Properties and mutation studies of a bacteriophage-derived chimeric recombinant staphylolytic protein P128
TLDR
Additional properties of P128 are disclosed and compared the same with lysostaphin and it is shown that arginine and cysteine, at 40th and 76th positions respectively, are critical for the staphylolytic activity of P 128, although these amino acids are not conserved residues. Expand
Bacteriophage lysins as antibacterials
TLDR
Keeping in mind the recent advances made in the area of discovery and clinical development of phage lysins to combat drug-resistant bacteria, it is proposed that lysin should also be highlighted as alternative options under the “non-antibiotic” approaches. Expand
Use of prophage free host for achieving homogenous population of bacteriophages: new findings.
TLDR
It is demonstrated for the first time that propagation of 44AHJD phage with endolysin supplementation in prophage free RN4220 host yields pure phage preparation. Expand
Phage therapy—bacteriophage and phage-derived products as anti-infective drugs
TLDR
This chapter describes the development path for phage-derived lysins, starting with discovery and leading to the strategy into the clinic, with P128, a novel chimeric antistaphylococcal lysin, as example. Expand
Influence ofEnhancer Sequences onThymotropism and Leukemogenicity ofMinkCellFocus-Forming Viruses
TLDR
The results show that pathogenic phenotypes of MCF viruses areissociable from thethymotropic phenotype anddepend, at least in part, upontheenhancer sequences, and it is suggested that the molecular mechanisms by which the enhancer sequences determine thymotropism are different from those thatdetermine oncogenicity. Expand