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Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
The crystal structures of two human dihydrofolate reductase (hDHFR) ternary complexes, each with bound NADPH cofactor and a lipophilic antifolate inhibitor, have been determined at atomic resolution.Expand
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Studies of the Biogenic Amine Transporters 15. Identification of Novel Allosteric Dopamine Transporter Ligands with Nanomolar Potency
Novel allosteric modulators of the dopamine transporter (DAT) have been identified. We have shown previously that SRI-9804 [N-(diphenylmethyl)-2-phenyl-4-quinazolinamine], SRI-20040Expand
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Structural elucidation of trichotetronines: polyketides possessing a bicyclo[2.2.2]octane skeleton with a tetronic acid moiety isolated from Trichoderma sp.
The isolation and structural elucidation of two novel fungal metabolites, trichotetronine and its dihydro congener, from Trichoderma sp. are described. The structures, including the relative andExpand
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Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase
ABSTRACT Development of new antimycobacterial agents for Mycobacterium avium complex (MAC) infections is important particularly for persons coinfected with human immunodeficiency virus. TheExpand
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Antiandrogenic phenolic constituents from Dalbergia cochinchinensis.
Four new compounds, 9-hydroxy-6,7-dimethoxydalbergiquinol, 6-hydroxy-2,7-dimethoxyneoflavene, 6,4'-dihydroxy-7-methoxyflavan and 2,2',5-trihydroxy-4-methoxybenzophenone, in addition to eight knownExpand
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Oligomannan synthesis using ionic liquid supported glycosylation.
The synthesis of complex oligosaccharides has been a challenge for researchers. Herein, we describe a strategy for the synthesis of an activated oligomannan 1 that employs ionic liquid (IL) supportExpand
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Imidazolium cation supported solution-phase assembly of homolinear alpha(1-->6)-linked octamannoside: an efficient alternate approach for oligosaccharide synthesis.
An efficient, simple convergent assembly of a homolinear alpha(1-->6)-linked octamannosyl thioglycoside was obtained starting from imidazolium cation-tagged mannosyl fluoride and thiomannoside usingExpand
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Phenolic constituents from Dalbergia cochinchinensis.
Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolatedExpand
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Annphenone, a phenolic acetophenone from Artemisia annua
Abstract Fractionation of the n -butanol extract of Artemisia annua led to the isolation of a new phenolic acetophenone, the structure of which was elucidated as 2,4-dihydroxy-6-methoxy-acetophenoneExpand
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