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Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells.
TLDR
Treg cells in MRL/lpr mice are not properly stimulated by APCs and are unable to suppress proinflammatory cytokine secretion from effector T cells.
Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus
TLDR
The tolerogenic peptide P140, which is recognized by lupus patients' CD4+ T cells and known to protect MRL/lpr mice, is able to thwart emergence of intermolecular T-cell spreading in treated animals.
Dynamics of Human Prothymocytes and Xenogeneic Thymopoiesis in Hematopoietic Stem Cell-Engrafted Nonobese Diabetic-SCID/IL-2rγnull Mice
TLDR
The data demonstrate that the developmental pattern of BM prothymocytes during human late fetal and early postnatal life can be reproduced in humanized mice, and suggest that onset of human thymus involution relates to decreased colonization by prostymocytes.
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
TLDR
It is indicated that AF1q cooperates with the Notch signaling pathway to foster the emergence of BM prothymocytes and drive subsequent intrathymic specification toward the T-cell lineage.
TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice
TLDR
This study highlights TCR signal strength associated with a higher TCR density as an important regulator of iNKT cell lineage specification as well as identifying a block in iN KT cell development at early developmental stages.
The association of Greig syndrome and mastocytosis reveals the involvement of hedgehog pathway in advanced mastocytosis.
TLDR
This work revealed, for the first time, the involvement of Hh signaling in the pathophysiology of mastocytosis and demonstrated the cooperative effects of the KIT and Hh oncogenic pathways in ASM, leading to the identification of new promising therapeutic targets.
Intramolecular T cell spreading in unprimed MRL/lpr mice: importance of the U1-70k protein sequence 131-151.
TLDR
This is the first study to demonstrate that intramolecular T cell spreading effectively occurs in MRL/lpr mice with lupus, and that region 131-151 is important in the cascade of events observed in the murine l upus response.
Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications
TLDR
Large-scale genomic DNA methylation analysis showed that balanced methylation changes occurred in about 200 genes following culture of CD34+ cells in the presence of cytokines but 900 genes were modified following addition of the LV, predominantly increasing CpG methylation.
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