Transcription factor RORα is critical for nuocyte development
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid… Expand
IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.
- J. Barlow, S. Peel, +11 authors A. McKenzie
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 October 2013
BACKGROUND IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. However, only… Expand
IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation
Interleukin‐33 (IL‐33) is an IL‐1 family cytokine that signals via its receptor T1/ST2, and is a key regulator of inflammation, notably the type‐2 response implicated in allergic asthma. Critical to… Expand
Receptor tyrosine phosphatase PTPγ is a regulator of spinal cord neurogenesis
- H. Hashemi, M. Hurley, +4 authors A. Stoker
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 February 2011
During spinal cord development the proliferation, migration and survival of neural progenitors and precursors is tightly controlled, generating the fine spatial organisation of the cord. In order to… Expand
Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil… Expand
Rorα is essential for nuocyte development
Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of asthma responses. Here we show that nuocytes arise in the bone marrow and differentiate from common lymphoid… Expand
Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event
As obligate parasites, viruses highjack, modify and repurpose the cellular machinery for their own replication. Viral proteins have, therefore, evolved biological functions, such as signalling… Expand
Metabolites produced by a mixed culture of anaerobic thermophilic cellulose bacteria.
Milk composition and its technological qualitites in Bulgarian Simmentals, Ayrshires, F1 crossbreds of these two breeds, and Holstein-Friesian cattle.
Gv1, a zinc finger gene controlling endogenous MLV expression.
The genomes of inbred mice harbor around 50 endogenous murine leukemia virus (MLV) loci, although the specific complement varies greatly between strains. The Gv1 locus is known to control the… Expand