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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
TLDR
It is speculated that the two major proteinopathies underlying AD biomarker changes, amyloid β (Aβ) and tau, might be initiated independently in sporadic AD, in which it is hypothesised that an incident Aβ pathophysiology can accelerate antecedent limbic and brainstem tauopathy. Expand
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
TLDR
A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer’s disease in the combined dataset. Expand
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
TLDR
Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance. Expand
The lifetime risk of suicide in schizophrenia: a reexamination.
TLDR
This study estimates that 4.9% of schizophrenics will commit suicide during their lifetimes, usually near illness onset. Expand
Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848Expand
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes
TLDR
A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer's Disease in the combined dataset. Expand
Genome-wide analysis of genetic loci associated with Alzheimer disease.
TLDR
Although CLU and PICALM were confirmed to be associated with AD in this independent sample, they did not improve the ability of a model that included age, sex, and APOE to predict incident AD. Expand
Affective disorders and suicide risk: a reexamination.
TLDR
A hierarchy of risk based on the intensity of the treatment setting is demonstrated among patients with affective disorders, showing that patients with a hospitalization history, particularly when suicidal, have a much elevated suicide prevalence over both psychiatric outpatients and nonpatients. Expand
Nurse staffing and inpatient hospital mortality.
TLDR
Staffing of RNs below target levels was associated with increased mortality, which reinforces the need to match staffing with patients' needs for nursing care. Expand
Association analysis identifies 65 new breast cancer risk loci
TLDR
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average. Expand
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