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Measurement of fibrinopeptide A in human blood.
TLDR
A radioimmunoassay for FPA is developed and the application of this assay to the measurement of FPA levels in clinical blood samples showed evidence that the immunoreactivity measured in plasma is due to FPA, and that extracts of streptokinasetreated plasma showed a five-fold increase in activity when treated with thrombin and markedly different immunore activity with the two antisera. Expand
Variation in biologic availability of digoxin from four preparations.
TLDR
In crossover studies in which 0.5 mg of digoxin was administered orally to normal volunteers, marked differences in serum digoxin levels achieved over a five-hour period were demonstrated. Expand
Digoxin-specific antibodies.
TLDR
The coupling of the cardiac glycoside, digoxin, to bovine serum albumin and the use of the resulting conjugate as an antigen to induce the formation of antibodies which exhibit digoxin specificity is described. Expand
Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of a multicenter study.
TLDR
Of patients who experienced cardiac arrest as a manifestation of digitalis toxicity, 54% survived hospitalization and 14 patients with adverse events considered to possibly or probably have been caused by Fab; the most common events were rapid development of hypokalemia and exacerbation of congestive heart failure. Expand
Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies.
TLDR
Purified Fab fragments of ovine digoxin-specific antibodies reversed severe digoxin intoxication in a patient who had taken 22.5 mg of the drug with suicidal intent, and these fragments are capable of rapid reversal of advanced digoxin toxicity. Expand
Inactivation of digoxin by the gut flora: reversal by antibiotic therapy.
TLDR
It is concluded that in some persons digoxin is inactivated by gastrointestinal bacteria, and changes in the enteric flora may markedly alter the state of digitalization. Expand
Progressive decrease in serum triiodothyronine concentrations with human aging: radioimmunoassay following extraction of serum.
TLDR
Serums from 127 seemingly healthy subjects aged 5 to 93 showed a statistically significant, progressive decrease for both sexes in T3 concentration with advancing age, amounting to 5.1 ng/dl per decade. Expand
Digoxin-inactivating bacteria: identification in human gut flora.
TLDR
Of hundreds of isolates studied, only Eubacterium lentum, a common anaerobe of the human colonic flora, converted digoxin to reduced derivatives, and neither the presence of these organisms alone nor their concentration within the gut flora appeared to determine whether digoxin would be inactivated by this pathway in vivo. Expand
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.
TLDR
A sensitive (0.2 ng per milliliter), precise, and specific radioimmunoassay for serum digoxin concentration has been developed, and may provide useful information to the clinician faced with the difficult problem of evaluating his patient's state of digitalization. Expand
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