• Publications
  • Influence
Going deeper than microscopy: the optical imaging frontier in biology
Optical microscopy has been a fundamental tool of biological discovery for more than three centuries, but its in vivo tissue imaging ability has been restricted by light scattering to superficialExpand
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Shedding light onto live molecular targets
Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infraredExpand
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Fluorescence molecular tomography resolves protease activity in vivo
Systematic efforts are under way to develop novel technologies that would allow molecular sensing in intact organisms in vivo. Using near-infrared fluorescent molecular beacons and inversionExpand
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Looking and listening to light: the evolution of whole-body photonic imaging
Optical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biologicalExpand
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Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improveExpand
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Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement.
We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG)Expand
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Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation.
We present a normalized Born expansion that facilitates fluorescence reconstructions in turbid, tissuelike media. The algorithm can be particularly useful for tissue investigations of fluorochromeExpand
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Fluorescence molecular imaging.
  • V. Ntziachristos
  • Medicine, Biology
  • Annual review of biomedical engineering
  • 11 July 2006
There is a wealth of new fluorescent reporter technologies for tagging of many cellular and subcellular processes in vivo. This imposed contrast is now captured with an increasing number of availableExpand
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MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions.
We present the clinical implementation of a novel hybrid system that combines magnetic resonance imaging (MRI) and near-infrared (NIR) optical measurements for the noninvasive study of breast cancerExpand
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A submillimeter resolution fluorescence molecular imaging system for small animal imaging.
Most current imaging systems developed for tomographic investigations of intact tissues using diffuse photons suffer from a limited number of sources and detectors. In this paper we describe theExpand
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