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Mechanical ventilation guided by esophageal pressure in acute lung injury.
TLDR
A ventilator strategy using esophageal pressures to estimate the transpulmonary pressure significantly improves oxygenation and compliance and Multicenter clinical trials are needed to determine whether this approach should be widely adopted.
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Prior Statin Therapy Is Associated With a Decreased Rate of Severe Sepsis
TLDR
Prior therapy with statins may be associated with a reduced rate of severe sepsis and intensive care unit (ICU) admission and statin treatment may have a role in the primary prevention of septicaemia.
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Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition.
TLDR
The Berlin definition is likely to underestimate the impact of ARDS in low-income countries, where resources to meet the definition requirements are lacking and further work in refining an ARDS definition that can be consistently used in all settings is stimulated.
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The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial
TLDR
Statin therapy may be associated with a reduction in the levels of inflammatory cytokines in patients with acute bacterial infections, and large controlled trials will determine if this reduction will translate into a clinical benefit.
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ICU admission characteristics and mortality rates among elderly and very elderly patients
TLDR
The proportion of elderly patients from the total ICU population is high, and with advancing age, the proportion of various preexisting comorbidities and the primary reason for ICU admission change should be regarded as a significant independent risk factor for mortality, especially for ICu patients older than 75.
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Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly.
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Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
TLDR
It is suggested that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients.
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Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure–Guided Strategy vs an Empirical High PEEP-FIO2 Strategy on Death and Days Free From Mechanical Ventilation…
TLDR
Among patients with moderate to severe ARDS, PES-guided PEEP, compared with empirical high PEEP-FIO2, resulted in no significant difference in death and days free from mechanical ventilation, and these findings do not support PES's guided PEEP titration in ARDS.
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Troponin criteria for myocardial infarction after percutaneous coronary intervention.
TLDR
Troponin and CKMB elevations after percutaneous coronary intervention are associated with increased 1-year mortality rates, but thresholds for similar event frequency and mortality hazard are much higher for troponin than for CKMB.
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Selective Molecular Potassium Channel Blockade Prevents Atrial Fibrillation
TLDR
Gene therapy with KCNH2-G628S eliminated AF by prolonging atrial action potential duration and loss of gene expression at day 21 correlated with loss of action potential prolongation and therapeutic efficacy.
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