• Publications
  • Influence
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysisExpand
  • 1,296
  • 110
  • PDF
HIF-1alpha is essential for myeloid cell-mediated inflammation.
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts ofExpand
  • 820
  • 69
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
The hypoxic response is an ancient stress response triggered by low ambient oxygen (O2) (ref. 1) and controlled by hypoxia-inducible transcription factor-1 (HIF-1), whose α subunit is rapidlyExpand
  • 1,083
  • 49
  • PDF
ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors
Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surfaceExpand
  • 699
  • 43
  • PDF
HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducibleExpand
  • 559
  • 40
  • PDF
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity
Golden color imparted by carotenoid pigments is the eponymous feature of the human pathogen Staphylococcus aureus. Here we demonstrate a role of this hallmark phenotype in virulence. Compared withExpand
  • 550
  • 37
  • PDF
DNase Expression Allows the Pathogen Group A Streptococcus to Escape Killing in Neutrophil Extracellular Traps
The innate immune response plays a crucial role in satisfactory host resolution of bacterial infection. In response to chemotactic signals, neutrophils are early responding cells that migrate inExpand
  • 599
  • 36
  • PDF
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts ofExpand
  • 1,412
  • 34
  • PDF
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote secretion of the proinflammatory cytokine IL-1β. Yet, the molecularExpand
  • 360
  • 28
  • PDF
Innate antimicrobial peptide protects the skin from invasive bacterial infection
In mammals, several gene families encode peptides with antibacterial activity, such as the β-defensins and cathelicidins. These peptides are expressed on epithelial surfaces and in neutrophils, andExpand
  • 1,144
  • 26
  • PDF