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Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program
TLDR
Gmnc is identified as an evolutionarily conserved master regulator functioning at the top of the hierarchy of transcription factors involved in MCC differentiation, and is shown to functions downstream of Notch signaling, but upstream of Multicilin in the developmental pathway controlling MCC specification. Expand
Mutations in CCDC11, which Encodes a Coiled‐Coil Containing Ciliary Protein, Causes Situs Inversus Due to Dysmotility of Monocilia in the Left–Right Organizer
TLDR
It is demonstrated that CCDC11 has a conserved essential function in cilia of the vertebrate LR organizer, which is the first ciliary component, which has a differential localization and function in different kinds of motile cilia. Expand
Cholera toxin increases the rate of antigen-stimulated calcium influx in rat basophilic leukemia cells.
TLDR
Data suggest that a cholera toxin-sensitive guanine nucleotide-binding protein is involved in the pathway responsible for the antigen-stimulated influx of calcium into RBL cells. Expand
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
TLDR
It is shown that Arl13b increases cilia length by inducing protrusion of the ciliary membrane, which is then followed by the extension of the axonemal microtubules, and it is established that the GTPase activity of the protein is essential for ciliary membranes extension. Expand
A guanine nucleotide-binding protein participates in IgE receptor-mediated activation of endogenous and reconstituted phospholipase A2 in a permeabilized cell system.
TLDR
Data indicate that receptor-mediated activation of a guanine nucleotide-binding protein can shift the Ca2+ dependence of PLA2 activity resulting in greatly enhanced activity at physiological concentrations of intracellular free Ca2+. Expand
Microfilaments regulate the rate of exocytosis in rat basophilic leukemia cells.
TLDR
Disruption of microfilaments in rat basophilic leukemia (RBL) cells by exposure to cytochalasin B is observed to potentiate the rate of antigen-stimulated secretion from these cells, and micro Filaments are proposed to regulate a terminal step in exocytosis, in a physiologically relevant manner. Expand
Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program
TLDR
A survey of numerous eukaryotic genomes is performed and evidence of a conserved ability of FoxJ1 proteins from a number of diverse phyletic groups to activate the expression of a host of motile ciliary genes in zebrafish embryos is obtained, providing the first evolutionary perspective into the transcriptional control of Motile ciliogenesis. Expand
Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program
TLDR
It has come to the authors' attention that the gmnc locus deletion characterization in the paper was incorrect, and several words on page 3267 of the main text, as well as Figures S1D and S1E and the corresponding sections in the Supplemental Experimental Procedures, have been corrected. Expand
The effects of the normal and oncogenic forms of the neu tyrosine kinase, and the corresponding forms of an immunoglobulin E receptor/neu tyrosine kinase fusion protein, on Xenopus oocyte maturation
TLDR
The results of these studies suggest that the activation of the p185neu tyrosine kinase by a point mutation within its membrane‐spanning helix, or an aggregation event, can result in the facilitation of oocyte maturation events that are elicited by other factors. Expand
Cilia: Organelles at the Heart of Heart Disease
TLDR
A genetic screen in mice shows that ciliary dysfunction may indeed be the major contributing factor in the etiology of congenital heart disease. Expand
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