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Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
Transcription factors (TFs) and their specific interactions with targets are crucial for specifying gene-expression programs. To gain insights into the transcriptional regulatory networks inExpand
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Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
Jmjd3, a JmjC family histone demethylase, is induced by the transcription factor NF‐kB in response to microbial stimuli. Jmjd3 erases H3K27me3, a histone mark associated with transcriptionalExpand
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Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serumExpand
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Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Human mononuclear phagocytes comprise phenotypically and functionally overlapping subsets of dendritic cells (DCs) and monocytes, but the extent of their heterogeneity and distinct markers for subsetExpand
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Five Myths about India's Nuclear Posture
For a democracy that otherwise leaks secrets like a sieve, India’s entire nuclear journey has been shrouded in remarkable secrecy. It is therefore unsurprising that India has closely guarded theExpand
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Functionally diverse human T cells recognize non-microbial antigens presented by MR1
MHC class I-related molecule MR1 presents riboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative antigens to other TExpand
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Who Are These Belligerent Democratizers? Reassessing the Impact of Democratization on War
In a key finding in the democratic peace literature, Mansfield and Snyder argue that states with weak institutions undergoing incomplete transitions to democracy are more likely to initiate anExpand
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IgG1 memory B cells keep the memory of IgE responses
The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is producedExpand
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Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults.
Background Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized the nutritional and metabolic profile ofExpand
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A CFD-Based Model for Predicting Shear-Induced DNA Breakage in Mix Tanks
Abstract A new approach to modeling the degradation kinetics of large biological macromolecules (i.e. DNA) in a mixing tank is proposed which utilizes Computation Fluid Dynamic Modeling (CFD). TheExpand
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