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Noninvasive Tim-3 Messenger RNA Evaluation in Renal Transplant Recipients With Graft Dysfunction
Background. Renal biopsies are usually needed to elucidate graft dysfunction. In this study, T-cell immunoglobulin domain, mucin domain mRNA expression in the peripheral blood leukocytes (PBL) andExpand
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Endothelin-1 and Endothelin A Receptor Immunoreactivity Is Increased in Patients with Diabetic Nephropathy
Background: Endothelin-1 (ET-1) is associated with progression of renal disease, acting as a vasoconstrictor and growth factor for mesangial cells. ET-1 and endothelin A receptor (ET-RA) might have aExpand
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Kidney injury molecule-1 expression in human kidney transplants with interstitial fibrosis and tubular atrophy
BackgroundKidney injury molecule-1 (KIM-1) is expressed in tubular epithelial cells after injury and may have a role in the development of renal graft fibrosis. In this study we evaluated theExpand
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Expression patterns of B cells in acute kidney transplant rejection.
OBJECTIVES To evaluate B-cell expression patterns and association with function and survival in dysfunctional kidney allografts. MATERIALS AND METHODS There were 110 kidney transplant recipientsExpand
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Clinical and pathological correlations of C4d immunostaining and its influence on the outcome of kidney transplant recipients.
INTRODUCTION C4d is a marker of antibody-mediated rejection (ABMR) in kidney allografts, although cellular rejection also have C4d deposits. OBJECTIVE To correlate C4d expression withExpand
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FOXP3+ regulatory T cells: from suppression of rejection to induction of renal allograft tolerance.
Naturally occurring and induced regulatory T cells (Tregs) can become hyporesponsive and anergic to antigen stimulation in autoimmune diseases and allograft rejection. The mechanisms of suppressionExpand
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Analysis of FOXP3 Gene and Protein Expressions in Renal Allograft Biopsies and Their Association with Graft Outcomes
Background: The transcription factor FOXP3 is increased in acute renal rejection, but its influence on graft outcomes is unclear. This study correlated FOXP3 with dendritic cells and graft outcomes.Expand
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Evaluation of apoptosis in peripheral blood lymphocytes of renal transplant patients.
The aim of this study was to evaluate the occurrence of apoptosis and the expression of FasL and IL-2 genes in apoptotic peripheral blood mononuclear cells (PBMC) at different posttransplant periods.Expand
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Correlações clinico-patológicas da marcação de C4d e sua influência na evolução de receptores de transplante renal
INTRODUCTION: C4d is a marker of antibody-mediated rejection (ABMR) in kidney allografts, although cellular rejection also have C4d deposits. OBJECTIVE: To correlate C4d expression withExpand
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